NDLI: Targeting regulated cell death in tumor nanomedicines

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Targeting regulated cell death in tumor nanomedicines

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Targeting regulated cell death in tumor nanomedicines

Content Provider	Ivyspring International Publisher
Author	Zeng, Qinghu Ma, Xiangyi Song, Yangmeihui Chen, Qiqing Jiao, Qiuling Zhou, Liqiang
Editor	Chen, Xiaoyuan (Shawn)
Abstract	Nanomedicines hold great potential in anticancer therapy by modulating the biodistribution of nanomaterials and initiating targeted oxidative stress damage, but they are also limited by the inherent self-protection mechanism and the evolutionary treatment resistance of cancer cells. New emerging explorations of regulated cell death (RCD), including processes related to autophagy, ferroptosis, pyroptosis, and necroptosis, substantially contribute to the augmented therapeutic efficiency of tumors by increasing the sensitivity of cancer cells to apoptosis. Herein, paradigmatic studies of RCD-mediated synergistic tumor nanotherapeutics are introduced, such as regulating autophagy-enhanced photodynamic therapy (PDT), targeting ferroptosis-sensitized sonodynamic therapy (SDT), inducing necroptosis-augmented photothermal therapy (PTT), and initiating pyroptosis-collaborative chemodynamic therapy (CDT), and the coordination mechanisms are discussed in detail. Multiangle analyses addressing the present challenges and upcoming prospects of RCD-based nanomedicines have also been highlighted and prospected for their further strengthening and the broadening of their application scope. It is believed that up-and-coming coadjutant therapeutic methodologies based on RCDs will considerably impact precision nanomedicine for cancer.
Related Links	https://www.thno.org/v12p0817.pdf
Ending Page	841
Starting Page	817
File Format	PDF
ISSN	18387640
DOI	10.7150/thno.67932
Journal	Theranostics
PubMed reference number	34976215
Issue Number	2
PubMed Central reference number	PMC8692918
Volume Number	12
Language	English
Publisher	Ivyspring International Publisher
Publisher Date	2022-01-01
Access Restriction	Open
Subject Keyword	Regulated cell death Tumor therapy Nanomedicine Sensitized apoptosis Nanomaterials Reviews
Content Type	Text
Resource Type	Review Article
Subject	Biochemistry, Genetics and Molecular Biology Medicine
Journal Impact Factor	13.3

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