NDLI: CONTROLLED RELEASE OF AMPHOTERICIN B FROM ELECTROSPUN NANOFIBER BASED ON GELATIN: A NEW INSIGHT TO DRUG DELIVERY AGAINST LESHMANIASIS

Content Provider	IIT Roorkee
Author	Nanda, Himansu Sekhar
Description	Electrospun nanofibers were developed as a new system for the delivery of a medical drug amphotericin B. In this study drug loaded nanofibers of average diameter of 100nm were fabricated from a natural biodegradable polymer based on gelatin by advanced electrospinning process. The fibers in our research were prepared from 10 wt. % gelatin in acetic acid and water mixed with 1. wt. % amphotericin B and characterized by the Field Emission Scanning Electron Microscopy (FE-SEM) for observation of fiber morphology. The chemical integrity of the drug in electrospun nanofibers were confirmed by Fourier Transformation Infra Red (FTIR) spectroscopic analysis and the release of the amphotericin B from the electrospun fibers were further investigated by UV-Vis spectrophotometer in phosphate buffer of PH 7.4 at normal body temperature of 37°C. The release profile suggests that electrospun amphotericin B loaded biodegradable micro and nanofibers may be promising for the treatment of leshmaniasis and several sever fungal infections as alternative drug delivery devices.
File Format	PDF
Language	English
Publisher Department	Department of Mechanical & Industrial Engineering
Access Restriction	Open
Subject Keyword	Nanotechnology
Content Type	Text
Educational Degree	Master of Technology (M.Tech.)
Resource Type	Thesis

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