NDLI: The DNA-binding protein HU is a molecular glue that attaches bacteria to extracellular DNA in biofilms

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M.S. Dissertation of Integrated PhD students on Biological Science

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PhD Thesis of Integrated PhD students on Biological Science

PhD Thesis of Integrated PhD students on Chemical Science

PhD Thesis of Integrated PhD students on Physical Science

PhD Thesis on Biological Science

PhD Thesis on Biotechnology

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PhD Thesis on Earth and Environmental Science

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Research Articles of 2008-2014

Research Articles of 2015-2016

Research Articles of 2017-2018

Research Articles of 2019-2020

Research Articles of 2021-2022

$Z_2$ symmetry in $Z_2+$ Higgs theory

2D weak anti-localization in thin films of the topological semimetal $Pd_3Bi_2S_2$

A Mouse Model of PPRV Infection for Elucidating Protective and Pathological Roles of Immune Cells

A Red-noise Eigen basis for the Reconstruction of Blobby Images

A Wells type exact sequence for non-degenerate unitary solutions of the Yang–Baxter equation

A cellular expression map of epidermal and subepidermal cell layer-enriched transcription factor genes integrated with the regulatory network in Arabidopsis shoot apical meristem

A comprehensive SARS-CoV-2 genomic analysis identifies potential targets for drug repurposing

A genome-wide association study reveals cytokinin as a major component in the root defense responses against Ralstonia solanacearum

A measurement of Hubble’s Constant using Fast Radio Bursts

A novel leishmanial copper P-type ATPase plays a vital role in parasite infection and intracellular survival

A review on synthetic methods for 2-Deoxy-D-glucose

Aberrant phase transitions of a pathological Stop codon mutant of the prion protein

Air pollution scenario analyses of fleet replacement strategies to accomplish reductions in criteria air pollutants and 74 VOCs over India

Alexander and Markov theorems for virtual doodles

An intrinsically disordered pathological prion variant Y145Stop converts into self-seeding amyloids via liquid–liquid phase separation

An introductory review on resource theories of generalized nonclassical light

Anisotropy in mechanical unfolding of protein upon partner-assisted pulling and handle-assisted pulling

Anomalous negative longitudinal magnetoresistance and violation of Ohm's law deep in the topological insulating regime in Bi1−xSbx

Antiferromagnetic skyrmion crystals in the Rashba Hund’s insulator on triangular lattice

Aspects of gravitational decoherence in neutrino lensing

AstroSat View of Blazar OJ 287: A complete evolutionary cycle of HBL Component from end-phase to disappearance and Re-emergence

AstroSat/UVIT observations of IC 4329A: Constraining the accretion disc inner radius

Atoms and molecules in a confined environment

Attaining Carnot efficiency with quantum and nanoscale heat engines

Attosecond stable dispersion-free delay line for easy ultrafast metrology

Bacterial supergroup-specific cost of Wolbachia infections in Nasonia Vitripennis

Bifurcation analysis of the predator–prey model with the Allee effect in the predator

Biodegradable Protein-Stabilized Inorganic Nanoassemblies for Photothermal Radiotherapy of Hepatoma Cells

Biogas Upgradation Through CO2 Conversion Into Acetic Acid via Microbial Electrosynthesis

Biomimics of phenazine oxidase activity of a cobalt (III)-dipyridylamine complex: Spectroscopic structural and computational studies

Broad-band spectral study of LMXB black hole candidate 4U 1957+11 with NuSTAR

Broader roles of the ubiquitin-like protein Hub1 indicated by its yeast two-hybrid interactors

COVID-19: disease, or no disease? - that is the question. It’s the dose stupid!

Career challenges for young independent researchers in India

Circuit complexity from cosmological islands

Coarse graining nonisothermal micro swimmer suspensions

Combination of Immunofluorescence and Quantitative Fluorescence In-situ Hybridization for Analysing Differential Gene Expression in the Niche Cells of the Drosophila Lymph Gland

Combined analysis of Belle and Belle II data to determine the CKM angle $ϕ_3$ using $B^+ → D(K_S^0h^+h^−)h^+$ decays: Erratum

Comparative assessment of TROPOMI and OMI formaldehyde observations and validation against MAX-DOAS network column measurements

Complex Langevin dynamics and supersymmetric quantum mechanics

Complex Langevin simulations for PT-symmetric models

Conformational Characteristics and Phase Behavior of Intrinsically Disordered Proteins─Where Physical Chemistry Meets Biology

Constraining the NuMI neutrino flux using inverse muon decay reactions in MINERvA

Construction of logic gates exploiting resonance phenomena in nonlinear systems

Continuous demixing transition of binary liquids: Finite-size scaling from the analysis of sub-systems

Controlling optical trapping of metal–dielectric hybrid nanoparticles under ultrafast pulsed excitation: a theoretical investigation†

Convergent evolution of a genomic rearrangement may explain cancer resistance in hystrico- and sciuromorpha rodents

Cryo-EM elucidates mechanism of action of bacterial pore-forming toxins

Curcumin Inhibits Membrane-Damaging Pore-Forming Function of the β-Barrel Pore-Forming Toxin Vibrio cholerae Cytolysin

Current Perspective on the Membrane-Damaging Action of Thermostable Direct Hemolysin, an Atypical Bacterial Pore-forming Toxin

Deciphering single- and multi-particle trapping dynamics under femtosecond pulsed excitation with simultaneous spatial and temporal resolution

Deconstructing the role of myosin contractility in force fluctuations within focal adhesions

Development of a Sustainable and Biodegradable Sonchus asper Cotton Pappus Based Piezoelectric Nanogenerator for Instrument Vibration and Human Body Motion Sensing with Mechanical Energy Harvesting Applications

Diagnostic evaluation of extreme winter rainfall events over the Arabian Peninsula using high-resolution weather research and forecasting simulations

Diagonal unitary and orthogonal symmetries in quantum theory

Discreteness Of Hyperbolic Isometries by Test Maps

Dithiothreitol causes toxicity in C. elegans by modulating the methionine-homocysteine cycle

Divector boson production in association with a Higgs boson at hadron colliders

Divergence of responses to variable socio-sexual environments in laboratory populations of Drosophila melanogaster evolving under altered operational sex ratios

Driven translocation of a semiflexible polymer through a conical channel in the presence of attractive surface interactions

Drosophila melanogaster hosts coevolving with Pseudomonas entomophila pathogen show sex-specific patterns of local adaptation

Dynamic noncommutative BTZ black holes

Editorial: Cell Organelle Exploitation by Viruses During Infection

Editorial: Life and work of Professor Govind Swarup

Editorial: Nucleic Acid Polymerases: The Two-Metal-Ion Mechanism and Beyond

Effect of Retinal Injury Induced by Laser Photocoagulation on Visuospatial Memory in Mouse Model

Electrochemical enrichment of haloalkaliphilic nitrate-reducing microbial biofilm at the cathode of bioelectrochemical systems

Enemies make you stronger: Coevolution between fruit fly host and bacterial pathogen increases postinfection survivorship in the host

Energy Research at ACS in the Age of Open Access

Enhanced Simulation of the Indian Summer Monsoon Rainfall Using Regional Climate Modeling and Continuous Data Assimilation

Enhanced optical force on multilayered dielectric nanoparticles by tuning material properties and nature of excitation: a theoretical investigation

Enhancement of extreme events through the Allee effect and its mitigation through noise in a three species system

Essential Role for an Isoform of Escherichia coli Translation Initiation Factor IF2 in Repair of Two-Ended DNA Double-Strand Breaks

Establishment of Repertoire of Placentome-Associated MicroRNAs and Their Appearance in Blood Plasma Could Identify Early Establishment of Pregnancy in Buffalo (Bubalus bubalis)

Ethanol-induced Sedative Behavior: An Assay to Investigate Increased Dopamine Signaling in Caenorhabditis elegans

Evaluating Winter Precipitation over the Western Himalayas in a High-Resolution Indian Regional Reanalysis Using Multisource Climate Datasets

Evidence for $X (3872) →j/ψ π^+ π^-$ produced in single-tag two-photon interactions

Evidence for profile changes in PSR J1713+0747 using the uGMRT

Evidence of hard power-law spectral cutoff and disc reflection features from the X-ray transient XTE J1739–285

Evolution of cross-tolerance in Drosophila melanogaster as a result of increased resistance to cold stress

Evolution of pathogen-specific improved survivorship post-infection in populations of Drosophila melanogaster adapted to larval crowding

Evolution of reproductive traits have no apparent life-history associated cost in populations of Drosophila melanogaster selected for cold shock resistance

Evolution of sex-specific heat stress tolerance and larval Hsp70 expression in populations of Drosophila melanogaster adapted to larval crowding

Excited state dynamics of BODIPY-based acceptor–donor–acceptor systems: a combined experimental and computational study

Excited state structural evolution in fluorescent proteins and their model chromophores

Exome sequencing identifies procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 mutations in primary congenital and juvenile glaucoma

Exotic image formation in strong gravitational lensing by clusters of galaxies - I

Exotic image formation in strong gravitational lensing by clusters of galaxies – II. Uncertainties

Exotic image formation in strong gravitational lensing by clusters of galaxies – III. Statistics with HUDF

Experimental demonstration of the violation of the temporal Peres-Mermin inequality using contextual temporal correlations and non-invasive measurements

Experimental evolution reveals sex-specific dominance for surviving bacterial infection in laboratory populations of Drosophila melanogaster

Experimental simulation of a monogamy relation between quantum contextuality and nonlocality on an NMR quantum processor

Exploring Gendered Perspectives on Working Conditions of Solo Self-Employed Quarry Workers in Ghana

Exploring neutrino–nucleus interactions in the GeV regime using Minerva

Exploring the new physics phases in 3+1 scenario in neutrino oscillation experiments

Exploring the novel mechanistic aspects of function of a hyperthermophile two-site exo-amylase-cum-glucanotransferase displaying substrate versatility

Exploring γ-Ray Flares in the Long-term Light Curves of CTA 102 at GeV Energies

Facile Synthesis of Pure and Cr-Doped WO3 Thin Films for the Detection of Xylene at Room Temperature

First determination of the spin and parity of the charmed-strange baryon ξc (2970)+

First measurement of the $Λ_c^+ → pη′$ decay

First test of lepton flavor universality in the charmed baryon decays $Ω_c^0 → Ω^{−} ℓ^+ ν_ℓ$ using data of the Belle experiment

Flexoelectric Polarization in a Nematic Liquid Crystal Enhanced by Dopants with Different Molecular Shape Polarities

Galaxy And Mass Assembly (GAMA): Data Release 4 and the z < 0.1 total and z < 0.08 morphological galaxy stellar mass functions

Generating Sustained Coherence in a Quantum Memory for Retrieval at Times of Quantum Revival

Gentamicin Augments the Quorum Quenching Potential of Cinnamaldehyde In Vitro and Protects Caenorhabditis elegans From Pseudomonas aeruginosa Infection

Global biogeography of warning coloration in the butterfly Danaus chrysippus

Glu289 residue in the pore-forming motif of Vibrio cholerae cytolysin is important for efficient β-barrel pore formation

Glyoxal tropospheric column retrievals from TROPOMI – multi-satellite intercomparison and ground-based validation

Gravitational Lensing of Gravitational Waves: Effect of microlens population in lensing galaxies

Gravitational Lensing of Gravitational Waves: Probability of microlensing in galaxy-scale lens population

HeH+ Collisions with H2: Rotationally Inelastic Cross Sections and Rate Coefficients from Quantum Dynamics at Interstellar Temperatures

How robust are the inferred density and metallicity of the circumgalactic medium?

Identification and characterization of a novel glutaminase inhibitor

Immunology to Immunotherapeutics of SARS-CoV-2: Identification of Immunogenic Epitopes for Vaccine Development

Immunoporosis: Role of Innate Immune Cells in Osteoporosis

Implementation of discrete positive operator valued measures on linear optical systems using cosine-sine decomposition

Implementing efficient selective quantum process tomography of superconducting quantum gates on IBM quantum experience

In memory of narinder singh kapany

Increased dopaminergic neurotransmission results in ethanol dependent sedative behaviors in Caenorhabditis elegans

Influencing Opinion Dynamics in Networks with Limited Interaction

Intermolecular CDC amination of remote and proximal unactivated $C_{sp}3–H$ bonds through intrinsic substrate reactivity – expanding towards a traceless directing group

Investigating the formation of diverse ZnO nanostructures based on solvent, temperature, and pH as adjustable parameters

Investigating the interaction between inter-locus and intra-locus sexual conflict using hemiclonal analysis in Drosophila melanogaster

Investment in adult reproductive tissues is affected by larval growth conditions but not by evolution under poor larval growth conditions in Drosophila melanogaster Author links open overlay panel

Iron homeostasis in plants and its crosstalk with copper, zinc, and manganese

Land Use Change and Prediction for Valuating Carbon Sequestration in Viti Levu Island, Fiji

Large-N limit of two-dimensional Yang--Mills theory with four supercharges

LeMMINGs – IV. The X-ray properties of a statistically complete sample of the nuclei in active and inactive galaxies from the Palomar sample

Ligand-redox assisted nickel catalysis toward stereoselective synthesis of (n+1)-membered cycloalkanes from 1,n-diols with methyl ketones

Liquid–liquid phase separation of tau: From molecular biophysics to physiology and disease

Long-term Multiband Near-infrared Variability of the Blazar OJ 287 during 2007–2021

Low-frequency wideband timing of InPTA pulsars observed with the uGMRT

Male mating success evolves in response to increased levels of male- male competition

Males of the parasitoid wasp Nasoniavitripennis can identify which fly hosts contain females

Master integrals for O(ααs) corrections to H → ZZ*

Measurement of $B(B_s → D_sX)$ with $B_s$ semileptonic tagging

Measurement of branching fraction and search for CP violation in B →φφK

Measurement of branching fractions and CP asymmetries for $d_s^+ →k^+ (η,π^0)$ and $d_s^+ →π^+ (η,π^0)$ decays at belle

Measurement of branching fractions of $Λ^+_c → ηΛπ^+, ηΣ^0π^+, Λ(1670)π^+,\ and\ ηΣ (1385)^+$

Measurement of inclusive charged-current ν μ cross sections as a function of muon kinematics at $⟨E_ν⟩ ∼ 6\ GeV$ on hydrocarbon

Measurement of inclusive charged-current ν μ scattering on hydrocarbon at ⟨ E ν ⟩ ∼ 6 GeV with low three-momentum transfer

Measurement of the branching fraction of $Λ^+_c→pω$ decay at Belle

Measurement of the branching fraction of the decay $B^+ → π^+π^− \ell^+ ν_ℓ$ in fully reconstructed events at Belle

Measurement of the branching fractions of the $B ^+ → η ^{ℓ +} \nu_ℓ$ and $B^+ → η′ ℓ ^+ \nu_ℓ$ decays with signal-side only reconstruction in the full $q^2$ range

Measurement of the energy dependence of the $e^+e^−→B\bar B, B\bar B^∗$ and $B^∗\bar B^∗$ exclusive cross sections

Measurement of the masses and widths of the $Σ_c(2455)^+$ and $Σ_c(2520)^+$ baryons

Measurement of time-dependent $CP$ violation parameters in $B^0 → K^0_SK^0_SK^0_S$ decays at Belle

Measurements of branching fractions and asymmetry parameters of $\Xi^0_c\to \Lambda\bar K^{*0}$, $\Xi^0_c\to \Sigma^0\bar K^{*0}$, and $\Xi^0_c\to \Sigma^+K^{*-}$ decays at Belle

Measurements of partial branching fractions of inclusive $B → X_u ℓ^+ \nu_ℓ$ decays with hadronic tagging

Measurements of q(2) moments of inclusive B -> X(c)l(+)upsilon(l) decays with hadronic tagging.

Measurements of the Branching Fractions of the Semileptonic Decays $Ξ^0_c → Ξ^− ℓ^+ ν_ℓ$ and the Asymmetry Parameter of $Ξ^0_c → Ξ^− π^+$

Measurements of the branching fractions of $\Lambda _c^+ →pη$ and $\Lambda_c^+ →pπ^0$ decays at belle

Measurements of the branching fractions of $Ξ^0_c → ΛK^0_S, Ξ^0_c → Σ^0K^0_S,\ and\ Ξ^0_c → Σ^+ K^−$ decays at Belle

Membership and age determination of M67 open cluster using GAIA EDR3 data

Microbially catalyzed bioelectrochemical power devices come of age

Mitochondrial Control of Stem Cell State and Fate: Lessons From Drosophila

Model Comparison of the Transverse Momentum Spectra of Charged Hadrons Produced in PbPb Collision at $√s_{NN}=5.02\ TeV$

Modulation of RecFORQ- and RecA-Mediated Homologous Recombination in Escherichia coli by Isoforms of Translation Initiation Factor IF2

Multi-stimuli programmable FRET† based RGB absorbing antennae towards ratiometric temperature, pH and multiple metal ion sensing

Natural and anthropogenic forces on suspended sediment dynamics in Asian estuaries

Neuropeptides and Behaviors: How Small Peptides Regulate Nervous System Function and Behavioral Outputs

Neutrino flavor oscillations in a rotating spacetime

New salts of levofloxacin with physiochemical, structural and biological insights

Nickel-Catalyzed Selective Synthesis of α-Alkylated Ketones via Dehydrogenative Cross-Coupling of Primary and Secondary Alcohols

No major cost of evolved survivorship in Drosophila melanogaster populations coevolving with Pseudomonas entomophila

Nocturnal Atmospheric Oxidative Processes in the Indo-Gangetic Plain and Their Variation During the COVID-19 Lockdowns

Non-Lorentzian chaos and cosmological holography

Non-perturbative phase structure of the bosonic BMN matrix model

Numerical Simulation of Winter Precipitation over the Western Himalayas Using a Weather Research and Forecasting Model during 2001–2016

Observation of “de Vries-like” properties in bent-core molecules

Organising as a catalyst for improving work conditions among informal quarry workers in Ghana

Oxadiazole-integrated heterocoronene discotics as ambipolar organic semiconductors

PT -symmetry and supersymmetry: interconnection of broken and unbroken phases

Pairing symmetries in the zeeman-coupled extended attractive hubbard model

Paul J. Crutzen (1933–2021)

Pd(II)-Catalyzed Directing-Group-Aided C–H Arylation and Alkylation of Pyrene Core: Synthesis of C1,C2- and C1,C10-Disubstituted Pyrene Motifs

Perpetuating enzymatically induced spatiotemporal pH and catalytic heterogeneity of a hydrogel by nanoparticles

Persistence of topological phases in non-hermitian quantum walks

Persistent impact of spring floods on crop loss in U.S. Midwest

Phase engineered gallium ferrite: a promising narrow bandgap, room-temperature ferroelectric

Polarization selective Dove prism

Polyhydroxyalkanoate synthase (PhaC): The key enzyme for biopolyester synthesis

Pore formation-independent cell death induced by a β-barrel pore-forming toxin

Post-typhoon forest damage estimation using multiple vegetation indices and machine learning models

Pre-optimization of the solvent of nanoparticle synthesis for superior catalytic efficiency: A case study with Pd nanocrystals

Probing non-standard HVV (V = W, Z) couplings in single Higgs production at future electron-proton collider

Properties of loss cone stars in a cosmological galaxy merger remnant

Protocol for bioelectrochemical enrichment, cultivation, and characterization of extreme electroactive microorganisms

Protocol for investigating the biogenesis of SARS-CoV-2 S pseudoviruses in HEK293T cells transduced to express the virus-specific intrabodies

Pyrophosphate release acts as a kinetic checkpoint during high-fidelity DNA replication by the Staphylococcus aureus replicative polymerase PolC

Quantifying spatio-temporal variation in aquaculture production areas in Satkhira, Bangladesh using geospatial and social survey

Quantitative Assessment of Nitrous Oxide Levels in Room Air of Operation Theaters and Recovery Area: An Observational Study

Quantum Heat Engines with Complex Working Media, Complete Otto Cycles and Heuristics

Quantum ghost imaging of a transparent polarisation sensitive phase pattern

Quantum heat engines with Carnot efficiency at maximum power

Quantum imaging of a polarisation sensitive phase pattern with hyper-entangled photons

Quantum theory of statistical radiation pressure in free space

Quinoline-tagged fluorescent organic probes for sensing of nitro-phenolic compounds and $Zn^{2+}$ ions at the ppb level

RTEII: A new high-resolution (0.1° × 0.1°) road transport emission inventory for India of 74 speciated NMVOCs, CO, NOx, NH3, CH4, CO2, PM2.5 reveals massive overestimation of NOx and CO and missing nitromethane emissions by existing inventories

RUFY1 binds Arl8b and mediates endosome-to-TGN CI-M6PR retrieval for cargo sorting to lysosomes

RUFY3 links Arl8b and JIP4-Dynein complex to regulate lysosome size and positioning

RUFY3 links Arl8b and JIP4-Dynein complex to regulate lysosome size and positioning

Recent advances in the elimination of persistent organic pollutants by photocatalysis

Records of fluid-rock interactions in the Degana tungsten deposit, India: Inferences from mineral paragenesis, whole-rock and mineral chemistry, and fluid inclusions

Regression plane concept for analysing continuous cellular processes with machine learning

Regulation of Metabotropic Glutamate Receptor Internalization and Synaptic AMPA Receptor Endocytosis by the Postsynaptic Protein Norbin

Relish plays a dynamic role in the niche to modulate Drosophila blood progenitor homeostasis in development and infection

Reply to “Comment on ‘Unified treatment of nonlinear optical force in laser trapping of dielectric particles of varying sizes’ ”

Revealing Thermal Comptonization of Accretion Disk Photons in IC 4329A with AstroSat

Robust anti-SARS-CoV2 single domain antibodies cross neutralize multiple viruses

Role for DNA double strand end-resection activity of RecBCD in control of aberrant chromosomal replication initiation in Escherichia coli

Role of Microglia and Astrocytes in Spinal Cord Injury Induced Neuropathic Pain

Salmonella Typhimurium Adhesin OmpV Activates Host Immunity To Confer Protection against Systemic and Gastrointestinal Infection in Mice

Search for $Z ′ → μ^+ μ^−$ in the $L_μ − L_tau$ gauge-symmetric model at Belle

Search for B 0 meson decays into Λ and missing energy with a hadronic tagging method at Belle

Search for charged lepton flavour violating decays of ϒ (1S)

Search for lepton-flavour-violating tau-lepton decays to ℓγ at Belle

Search for tetraquark states $X_{cc\bar{s}\bar{s}}$ in $D^+_sD^+_s(D^{*+}_sD^{*+}_s)$ final states at Belle

Search for the dark photon in $B^0 → A′A′,A′ → e^+ e^−, μ^+ μ^−,\ and\ π^+ π^−$ decays at belle

Search for the decay $B^0_s → η ′ K^0_S$

Search for the decay $B^0_s → η′η$

Search for the decay B^0_s→ηη$

Search for the in at near 10.6 GeV at belle

Search for the radiative penguin decays $B^0 → K^0_SK^0_Sγ$ in the Belle experiment

Single- droplet vibrational Raman spectroscopy illuminates the inner workings of phase- separated biomolecular condensates

Single-droplet surface-enhanced Raman scattering decodes the molecular determinants of liquid-liquid phase separation

Skeleton Ideals of Certain Graphs, Standard Monomials and Spherical Parking Functions

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Small molecules playing big roles: Tuning material properties of nucleolar condensates

Spatio-temporal variations in the water quality of the Doorndraai Dam, South Africa: An assessment of sustainable water resource management

Spectral States of OJ 287 blazar from Multiwavelength Observations with AstroSat

Spectroscopic evidence of mixed angular momentum symmetry in non-centrosymmetric $Ru_7B_3$

Sperm depletion in relation to developmental nutrition and genotype in Drosophila melanogaster

Splicing of branchpoint-distant exons is promoted by Cactin Tls1 and the ubiquitin- fold-activated Sde2

Split metacyclic actions on surfaces

Stability of a Viable Non-Minimal Bounce

Structural Controls Over the 2019 Ridgecrest Earthquake Sequence Investigated by High-Fidelity Elastic Models of 3D Velocity Structures

Structural basis for cytoplasmic dynein-1 regulation by Lis1

Study of $\bar{B}^0 → D^+h^−(h = K/π)$ decays at Belle

Study of $e^+ e^− → \Upsilon ( 1S, 2S ) η$ and $e^+ e^− → \Upsilon (1S) η′ $ at $√ s = 10.866\ GeV$ with the Belle detector

Studying the effect of a fluctuating environment on intra-atomic frequency comb based quantum memory

Substoichiometric Hsp104 regulates the genesis and persistence of self-replicable amyloid seeds of Sup35 prion domain

Substrate promiscuity: a continuum feature of enzymes

Superconductivity in silicon

Superelasticity of Plasma- and Synthetic Membranes Resulting from Coupling of Membrane Asymmetry, Curvature, and Lipid Sorting

Systematic review and meta-analysis of human genetic variants contributing to COVID-19 susceptibility and severity Author links open overlay panel

TLR9 signalling activation via direct ligation and its functional consequences in CD4 + T cells

Targeting dendritic cells with TLR-2 ligand–coated nanoparticles loaded with Mycobacterium tuberculosis epitope induce antituberculosis immunity

Test of Lepton-Flavour Universality in $B → K^∗ ℓ^+ ℓ^−$ Decays at Belle

Test of lepton flavour universality and search for lepton flavour violation in B → Kℓℓ decays

The AstroSat Observatory

The DNA-binding protein HU is a molecular glue that attaches bacteria to extracellular DNA in biofilms

The European Physical Society Conference on High Energy Physics (EPS-HEP2021) - T08: Flavour Physics and CP Violation

The G-Protein-Coupled Receptor SRX-97 Is Required for Concentration-Dependent Sensing of Benzaldehyde in Caenorhabditis elegans

The Generalized OTOC From Supersymmetric Quantum Mechanics: Study of Random Fluctuation Eigenstate Representation of Correlation Functions

The Hi Mass Function of Star-forming Galaxies at z ∼ 0.35

The Remarkable Spin-down and Ultrafast Outflows of the Highly Pulsed Supersoft Source of Nova Herculis 2021

The complex intracluster medium of Abell 1569 and its interaction with central radio galaxies

The evolving radio jet from the neutron star X-ray binary 4U 1820-30

The improved comparative reactivity method (ICRM): measurements of OH reactivity under high-NOx conditions in ambient air

The pressure- enhanced superconducting phase of $Sr_ x –Bi_ 2 Se_3$ probed by hard point contact spectroscopy

The receptor kinase SRF3 coordinates iron-level and flagellin dependent defence and growth responses in plants

The role of GPR56/ADGRG1 in health and disease

The super-soft source phase of the recurrent nova V3890 Sgr

The tale of three landslides in the Western Ghats, India: lessons to be learnt

The taxonomic impediment: a shortage of taxonomists, not the lack of technical approaches

Thermal phase structure of dimensionally reduced super-Yang-Mills

Thermonuclear X-ray bursts from 4U 1636 - 536 observed with AstroSat

Thienyltriazine based conjugated porous organic polymers: tuning of the porosity and band gap, and $CO_2$ capture

Time-dependent quantum mechanical wave packet dynamics

Topoisomerase I Essentiality, DnaA-Independent Chromosomal Replication, and Transcription-Replication Conflict in Escherichia coli

Transient State Kinetics of Plasmodium falciparum Apicoplast DNA Polymerase Suggests the Involvement of Accessory Factors for Efficient and Accurate DNA Synthesis

Tropylium Salt-Promoted Vinylogous Aza-Michael Addition of Carbamates to para-Quinone Methides: Elaboration to Diastereomerically Pure α,α′-Diarylmethyl Carbamates

Ubx-Collier signalling cascade maintains blood progenitors in the posterior lobes of the Drosophila larval lymph gland

Ultrathin picoscale white light interferometer

Understanding the Influence of Meteorology and Emission Sources on PM2.5 Mass Concentrations Across India: First Results From the COALESCE Network

Unified treatment of nonlinear optical force in laser trapping of dielectric particles of varying sizes

Unique Signatures of Rashba Effect in Angle Resolved Magnetoresistance

Universal Stokes’s nanomechanical viscometer

Unruh-DeWitt detector responses for complex scalar fields in de Sitter spacetime

Vegetation History in a Peat Succession Over the Past 8,000 years in the ISM-Controlled Kedar Nath Region, Garhwal Himalaya: Reconstruction Using Molecular Fossils

Weakening of interaction networks with aging in tip-link protein induces hearing loss

Widely tunable XUV harmonics using double IR pulses

X-ray confirmation of the intermediate polar IGR J16547-1916

X-ray observations of 1ES 1959+650 in its high-activity state in 2016–2017 with AstroSat and Swift

Zero-divisors and idempotents in quandle rings

l-Tyrosine derived fluorescent molecular probes as solvent mediated flip-flop halide (iodide/fluoride) sensors and reversible chromogenic pH indicators

The DNA-binding protein HU is a molecular glue that attaches bacteria to extracellular DNA in biofilms

Content Provider	IISER Mohali
Author	Thakur, Bhishem Gupta, Archit Arora, Kanika Guptasarma, P.
Abstract	In biofilms, bacteria that possess a negatively charged surface are embedded within a matrix of polymers consisting mainly of negatively charged extracellular DNA (e-DNA). In all likelihood, a multivalent positively charged substance, for example, a basic protein, exists within biofilms to neutralize charge-charge repulsions and act as a 'glue' attaching negatively charged bacteria to negatively charged e-DNA; however, no protein capable of doing so has yet been identified. We decided to investigate whether a highly abundant nucleoid-associated histone-like protein (HU) happens to be the glue in question. In recent years, HU has been shown to possess qualities that could be considered desirable in the proposed glue, for example, (a) availability in association with e-DNA; (b) multivalent DNA binding; (c) non-sequence-specific DNA-binding; (d) enhancement of biofilm formation upon exogenous addition, and (e) disruption of biofilms, upon removal by HU-cognate antibodies. Geometric considerations suggest that basic residues in HU's canonical and noncanonical DNA-binding sites can interact with sugar-linked terminal phosphates in lipopolysaccharide (LPS) molecules in bacterial outer membranes. Here, using genetic, spectroscopic, biophysical-chemical, microscopy-based, and cytometry-based experiments, we demonstrate that HU's DNA-binding sites also bind to LPS, that this facilitates DNA-DNA, DNA-LPS, and LPS-LPS interactions, and that this facilitates bacterial clumping and attachment of bacteria to DNA. Exogenous addition of HU to bacteria in (nonshaken) cultures is shown to cause cells to become engulfed in a matrix of DNA, potentially arising from the lysis of bacteria with vulnerable cell walls (as they strain to grow, divide, and move away from each other, in opposition to the accreting influence of HUs).
File Format	PDF
ISSN	00219258
e-ISSN	1083351X
Alternate Webpage(s)	http://210.212.36.82:8080/jspui/handle/123456789/4427?mode=full
Volume Number	296
Journal	Journal of Biological Chemistry
Language	English
Publisher	Elsevier
Publisher Date	2021-01-01
Access Restriction	Open
Subject Keyword	Nucleoid associated protein Bacterial Biofilm Bacterial cell-DNA binding glue Bacterial Clumping
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology Microbiology

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2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in