Development of Palladium Nanocatalysts for Carbon-Carbon Coupling Reactions

Content Provider	IISER Kolkata
Advisor	Mandal, Swadhin K.
Researcher	Santra, Subhankar
Abstract	Carbon−carbon coupling reaction is broadly recognized as a reaction in which two different fragments are connected by a single C−C bond e.g., Suzuki, Heck, Sonogashira or Ullmann coupling reactions. The immense economic value of C-C coupling reaction in pharmaceutical industries has already been recognized with the award of Nobel Prize in Chemistry in 2010. The design, synthesis, and testing efficient catalysts for the C−C bond formation processes are part of the ongoing search to generate more competent and cost effective catalyst. Recent trend in this area considers the use of palladium nanoparticles (PdNPs) as a promising alternative for the search of milder catalysts under environmentally benign methods avoiding the use of noxious phosphine ligands. The high surface-to-volume ratio of the PdNPs having more active surface atoms compared to those of the bulk catalysts can promote C−C coupling reactions under milder condition. Furthermore, the use of solid supported heterogeneous PdNPs allows the development of “ligand-free” catalysis resulting in cost reduction, simplifying workup procedures and recycling the catalysts for a number of successive catalytic runs. The major objective of the present study is the development of recyclable palladium nanocatalysts for carrying out a number of C−C coupling reactions such as Ullmann coupling reaction, acyl Sonogashira reaction and Suzuki-Miyaura reaction under mild condition. This study emphasizes the development of palladium nanocatalysts aiming at the synthesis of important drug molecules with high recycling efficiency.
File Format	PDF
Language	English
Access Restriction	Authorized
Subject Keyword	Nanocatalysts Palladium Nanocatalysts Graphite Oxide Ullmann Coupling Reaction Palladium Carbon-Carbon Coupling Catalysis
Content Type	Text
Educational Degree	Doctor of Philosophy (Ph.D.)
Resource Type	Thesis