NDLI: Horseradish Peroxidase Inhibition And Antioxidant Activity Of Ebselen And Related Organoselenium Compounds

Content Provider	Indian Institute of Science (IISc)
Author	Mishra, Beena Priyadarsini, K. I. Mohan, Hari Mugesh, G.
Copyright Year	2006
Abstract	Horseradish peroxidase (HRP) inhibition and glutathione peroxidase (GPx) activities of ebselen and some related derivatives are described. These studies show that ebselen and ebselen ditelluride $(EbTe_2)$ with significant antioxidant activity, inhibit the HRP-catalyzed oxidation reactions. In addition, inhibition of lipid peroxidation and singlet oxygen quenching studies were carried out. Although the inhibition of HRP by ebselen is comparable with that of $EbTe_2$, the inhibitory effect on c-radiation induced lipid peroxidation and the GPx activity of ebselen is found to be much higher than that of $EbTe_2$.
File Format	PDF
Journal	PeerReviewed
Language	English
Publisher	Elsevier
Publisher Date	2006-10-01
Access Restriction	Authorized
Subject Keyword	Inorganic & Physical Chemistry
Content Type	Text
Resource Type	Article

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