NDLI: Sensitive electrochemical biosensing of H2O2 based on cobalt nanoparticles synthesised in iron storage protein molecules, ferritin

Content Provider	IET Digital Library
Author	Rafipour, Ronak Kashanian, Soheila Tarighat, Fereshteh Abasi
Abstract	In this report, a highly sensitive electrochemical biosensor based on cobaltferritin immobilised on a self-assembled monolayer modiﬁed gold electrode for determination of hydrogen peroxide (H2O2) in phosphate buffer solution (pH 7.5) was investigated. The modiﬁed electrode showed excellent electrochemical activity for oxidation of H2O2. The response to H2O2 on the modiﬁed electrode was examined using linear sweep and differential pulse voltammetries. In phosphate buffer (pH 7.5, 0.1 M), the fabricated biosensor exhibited a linear dependence (R = 0.989) on the concentration of H2O2 from 2.49 × 10−9 to 1.91 × 10−8 M, a high sensitivity of −0.4099 µA/nM and detection limit of 2.48 × 10−9 based on a signal-to-noise ratio of 3. Charge transfer coefﬁcient (α) and the exchange current (i 0) of oxidation for H2O2 were found to be 0.57 and 7.55 A, respectively. It has been shown that, this modiﬁed electrode is able to determine H2O2 with a high sensitivity, low detection limit and high selectivity.
Starting Page	196
Ending Page	200
Page Count	5
ISSN	17518741
Volume Number	8
e-ISSN	1751875X
Issue Number	Issue 4, Dec (2014)
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/iet-nbt/8/4
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/10.1049/iet-nbt.2013.0050
Journal	IET Nanobiotechnology
Publisher Date	2014-05-16
Access Restriction	Open
Rights Holder	© The Institution of Engineering and Technology
Subject Keyword	Biochemistry Biosensor Charge Transfer Coefficient Chemical Analysis Chemical Sensor Chemical Variables Measurement Cobalt Cobalt Nanoparticles Current 0.57 A Current 7.55 A Differential Pulse Voltammetry Electrochemical Activity Electrochemical Analytical Method Electrochemical Electrodes Electrochemical Sensor Electrochemistry And Electrophoresis Electrode Exchange Current Ferritin Gold H2O2 High Selectivity High Sensitivity Hydrogen Compound Iron Storage Protein Molecule Linear Sweep Voltammetry Low Detection Limit Microsensors And Nanosensors MonoLayer Nanobiotechnology Nanoparticle Nanosensor Oxidation PH Phosphate Buffer Solution Physical Chemistry of Biomolecular Solutions And Condensed State Reaction Mechanisms Self-assembled Monolayer Self-assembly Sensitive Electrochemical Biosensing Specific Chemical Reactions Voltammetry
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Electronic, Optical and Magnetic Materials Electrical and Electronic Engineering Biotechnology

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