NDLI: High performance integrated terahertz sensor for detection of biomolecular processes in solution

Content Provider	IET Digital Library
Author	Matvejev, Vladimir Zhang, Yuchen Stiens, Johan
Abstract	Biomolecular processes occurring within a physiological buffer induce changes in the dielectric permittivity of the solution at terahertz frequencies (0.1–10 THz). Therefore novel high sensitivity THz sensors could potentially satisfy the need for a label-free, immobilisation-free, real-time and in-solution biosensor technology. However, the application is hindered by insufficient performance of current measurement techniques resulting in low sensitivity, low resolution, high detection limit and excessive sample volume. This work presents an integrated THz sensor topology designed to overcome the aforementioned challenges, performance evaluation with a number of typical biomolecule processes, and analysis of possible applications. The state-of-the-art performance is demonstrated with room-temperature operated solid-state active components operating at f ≃ 0.25 THz: the sample volume is V = 4 nl, detection limit is DL <9 mg/l, sensitivity to biomolecule concentration, conformation and binding. The technology could become a versatile tool for hydration shell study, protein conformation and function analysis, concentration measurements including nucleic acid amplification by polymerase chain reaction, protein and nucleic acid binding assay.
Starting Page	394
Ending Page	400
Page Count	7
ISSN	17518725
Volume Number	8
e-ISSN	17518733
Issue Number	Issue 6, Apr (2014)
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/iet-map/8/6
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/10.1049/iet-map.2013.0366
Journal	IET Microwaves, Antennas & Propagation
Publisher Date	2014-01-08
Access Restriction	Open
Rights Holder	© The Institution of Engineering and Technology
Subject Keyword	Biomolecular Process Biomolecule Concentration Biosensor Biosensor Technology Chemical Variables Measurement Concentration Measurement Dielectric Permittivity Frequency 0.1 THz to 10 THz Function Analysis Hydration Shell Study Integrated Terahertz Sensor Molecular Biophysics Nucleic Acid Amplification Nucleic Acid Binding Assay Performance Evaluation Photonic Technology Polymerase Chain Reaction Protein Conformation Solid State Active Component Temperature 293 K to 298 K
Content Type	Text
Resource Type	Article
Subject	Electrical and Electronic Engineering

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