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| Content Provider | IET Digital Library |
|---|---|
| Author | Moghaddam, Mohammad Pourhassan Zarghami, Nosratollah Mohsenifar, Afshin Yamchi, Mohammad Rahmati Gholizadeh, Davud Akbarzadeh, Abolfazl Guardia, Miguel de la Koshki, Kazem Nejati |
| Abstract | To avoid the potential adverse effects of chemically-synthesised gold nanoparticles (AuNPs), a new method is developed for their biosynthesis using watercress total extract (WTE) and it is compared it with the citrate-based method. Synthesised AuNPs were characterised using transmission electron microscopy (TEM), particle size analysis and infrared spectroscopy (FTIR), and the mechanism and biocompatibility of WTE-based AuNPs were evaluated by MTT assay. The colour of the WTE-based AuNPs was directly changed from yellow to deep red without any intermediate colour change and spectrophotometric analysis showed significant differences in absorbance as well as peak surface plasmon resonance of synthesised AuNPs as compared with the use of sodium citrate. Formation of AuNPs in the WTE-based method was faster than the method using citrate. TEM pictures showed similar sizes of the AuNPs obtained by both methods, but WTE-based AuNPs were more spherical and the range of sizes provided minor differences with TEM results. FTIR confirmed the involvement of WTE compounds in the structure of AuNPs during biosynthesis and the MTT assay did not show any considerable anti-growth effect of WTE-based AuNPs on target cells. Hence, it seems clear that WTE-AuNPs could be used for various biological-related purposes including drug delivery, diagnosis and treatment of various diseases. |
| Starting Page | 345 |
| Ending Page | 350 |
| Page Count | 6 |
| Volume Number | 9 |
| e-ISSN | 17500443 |
| Issue Number | Issue 5, May (2014) |
| Alternate Webpage(s) | https://digital-library.theiet.org/content/journals/mnl/9/5 |
| Alternate Webpage(s) | https://digital-library.theiet.org/content/journals/10.1049/mnl.2014.0063 |
| Journal | Micro & Nano Letters |
| Publisher Date | 2014-05-12 |
| Access Restriction | Open |
| Rights Holder | © The Institution of Engineering and Technology |
| Subject Keyword | Biocompatibility Biomedical Material Biosynthesis Cellular Biophysics Chemically-synthesised Gold Nanoparticles Citrate-based Method Collective Excitations (surface States) Disease Diagnosis Disease Treatment Drug Delivery System Fourier Transform Spectra FTIR Gold Infrared And Raman Spectra in Metals Infrared Spectra Infrared Spectroscopy Method of Nanofabrication And Processing MTT Assay Nanofabrication Nanomedicine Nanoparticle Nanotechnology Application in Biomedicine Nanotube And Nanostructured Material Particle Size Particle Size Analysis Spectrophotometric Analysis Spectrophotometry Structure of Solid Clusters Surface Plasmon Polariton Propagation Property Target Cell TEM Transmission Electron Microscopy Watercress Total Extract Watercress-based Gold NanoParticle |
| Content Type | Text |
| Resource Type | Article |
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