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| Content Provider | IET Digital Library |
|---|---|
| Author | Arízaga, Gregorio Guadalupe Carbajal Jiménez, Cecilia Sánchez Saavedra, Karina J. Parra Lamas, Adriana M. Macías Pérez, Ana M. Puebla |
| Abstract | Layered double hydroxides (LDH) are matrices with interlayer anions that can be exchanged with several types of organic or inorganic anions. Due to the anion-exchange capability, hundreds of new materials have been prepared in the past two decades. Conversely, attempts to intercalate neutral molecules (and increase the range of applications) have been achieved by expanding the interlayer space with long-chain surfactants, thus allowing to exclusively retain highly hydrophobic molecules. This work describes a folate-intercalated LDH structure, where folate pillars are capable of forming both hydrogen bonds and hydrophobic interactions with neutral molecules. Infrared spectroscopy and X-ray diffraction data indicated that imidazole, urea and cyclophosphamide were successfully intercalated. This evidence increases the opportunity to prepare more novel materials with neutral molecules in LDH. The cyclophosphamide-LDH product here obtained represents a remarkable example of an LDH-based vehicle for a non-ionic anti-cancer drug used in current chemotherapies. |
| Starting Page | 360 |
| Ending Page | 362 |
| Page Count | 3 |
| Volume Number | 11 |
| e-ISSN | 17500443 |
| Issue Number | Issue 7, Jul (2016) |
| Alternate Webpage(s) | https://digital-library.theiet.org/content/journals/mnl/11/7 |
| Alternate Webpage(s) | https://digital-library.theiet.org/content/journals/10.1049/mnl.2016.0106 |
| Journal | Micro & Nano Letters |
| Publisher Date | 2016-07-01 |
| Access Restriction | Open |
| Rights Holder | © The Institution of Engineering and Technology |
| Subject Keyword | Biomedical Material Cancer Chemotherapy Cyclophosphamide-LDH Product Drug Delivery System Drugs Folate-intercalated LDH Hydrogen Bond Hydrophobic Interaction Hydrophobic Molecule Imidazole Infrared Spectra Infrared Spectroscopy Inorganic Anion Interlayer Anion Interlayer Space Layered Double Hydroxide LDH-based Vehicle Long-chain Surfactant Neutral Molecule Nonionic Anticancer Drug Patient Care And Treatment Urea X-Ray Diffraction |
| Content Type | Text |
| Resource Type | Article |
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