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| Content Provider | IET Digital Library |
|---|---|
| Author | Wang, Jianmin Sun, Hao Liu, Xin |
| Abstract | The release behaviour and kinetic evaluation of resveratrol (Res) from nanostructured lipid carrier (NLC) have been conducted after characterisation for Res-NLC in this study. High-pressure microfluidisation technique was successfully applied to manufacturing Res-NLC, and the morphology of nanoparticle was observed via freeze-fracture transmission electron microscopy. Photon correlation spectroscopy was used to characterise the NLC system for particle size (PS) and polydispersity index (PDI). The in vitro release research was implemented by the dialysis method with active ingredient determined by high-performance liquid chromatography. Fitting of release data to different kinetic models was carried out. The optimised Res-NLC was physically stable with the PS below 200 nm, PDI below 0.3 and zeta potential (ZP) above 50 mV. The encapsulation efficiency was above 80%. Moreover, an in vitro release analysis demonstrated the sustained release profile of contents from NLC formulation over 12 h, with about 90% of the active ingredient released. Res-NLC presented the best fit with the Weibull model accompanied by better correlation value. In conclusion, all the obtained results demonstrated that the release study of Res-loaded NLC exhibited the promising application of the NLC formulation system in active ingredient sustained release carrier. |
| Starting Page | 697 |
| Ending Page | 702 |
| Page Count | 6 |
| Volume Number | 15 |
| e-ISSN | 17500443 |
| Issue Number | Issue 10, Aug (2020) |
| Alternate Webpage(s) | https://digital-library.theiet.org/content/journals/mnl/15/10 |
| Alternate Webpage(s) | https://digital-library.theiet.org/content/journals/10.1049/mnl.2020.0236 |
| Journal | Micro & Nano Letters |
| Publisher Date | 2020-08-19 |
| Access Restriction | Open |
| Rights Holder | © The Institution of Engineering and Technology |
| Subject Keyword | Applied Fluid Mechanics Biomedical Material BioMEMS Chromatography Drug Delivery System Drugs Electrochemistry And Electrophoresis Electrokinetic Effects Encapsulation Fracture Freeze-fracture Transmission Electron Microscopy Freezing High-performance Liquid Chromatography High-pressure Microfluidisation MEMS And NEMS Device Technology Microfluidics Micromechanical And Nanomechanical Device And System Nanodelivery System Nanofabrication Nanomedicine Nanoparticle Nanostructured Lipid Carrier Nanotechnology Application in Biomedicine Nanotube And Nanostructured Material Particle Size Patient Care And Treatment Photon Correlation Spectroscopy Polydispersity Index Resveratrol Structure of Solid Clusters Time 12.0 Hour Transmission Electron Microscopy Weibull Distribution Weibull Model Zeta Potential |
| Content Type | Text |
| Resource Type | Article |
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