NDLI: Insulin stabilisation in artificial pancreas: a positive control approach

Content Provider	IET Digital Library
Author	Leyva, Horacio Quiroz, Griselda Carrillo, Francisco A. Femat, Ricardo
Abstract	In the therapy of type 1 diabetes, artificial pancreas (AP) involves the automatic insulin delivery. The control problem in AP has been formulated to regulate glucose into its physiological range without accounting for dynamical effects of the delivered insulin. To address this problem, a control scheme to stabilise the insulin is proposed. The method shows that insulin stabilisation is reached and it is further improved while glucose remains into its range. Glucose metabolism is represented by a physiological and compartmental mathematical model, which consists of three interconnected subsystems called glucose, insulin and glucagon subsystems. In particular, the insulin subsystem is a positive linear system, thus it is possible to exploit its properties to propose a stabilisation scheme via positive control. Two approaches are presented: one based on sliding mode theory, and other based on control Lyapunov function theory. Some conditions are stated for the existence of stabilising controllers that improve the stabilisation rate while they take advantage of the cascade structure of the physiological model to maintain glucose into its range. A further application of these schemes is regarding safety of AP, preventing hypoglycaemia and/or hyperinsulinemia induced by a possible overreaction of AP's control schemes.
Starting Page	970
Ending Page	978
Page Count	9
ISSN	17518644
Volume Number	13
e-ISSN	17518652
Issue Number	Issue 7, Apr (2019)
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/iet-cta/13/7
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/10.1049/iet-cta.2018.5295
Journal	IET Control Theory & Applications
Publisher Date	2018-10-03
Access Restriction	Open
Rights Holder	© The Institution of Engineering and Technology
Subject Keyword	APs Control Scheme Artificial Organs Artificial Pancreas Automatic Insulin Delivery Biochemistry Cascade System Closed Loop System Compartmental Mathematical Model Diseases Glucagon SubSystem Glucose Metabolism Glucose Subsystem Hyperinsulinemia Hypoglycaemia Insulin Stabilisation Insulin Subsystem Interconnected SubSystem Linear System Lyapunov Function Theory Lyapunov Method Medical Control System Multivariable Control System Patient Treatment Physiological Model Physiological Range Position Control Positive Control Approach Positive Linear System Prosthetic And Orthotic Control System Spatial Variables Control Stabilisation Rate Stabilisation Scheme Stability in Control Theory Type 1 Diabetes Mellitus Variable Structure System
Content Type	Text
Resource Type	Article
Subject	Control and Optimization Control and Systems Engineering Human-Computer Interaction Electrical and Electronic Engineering Computer Science Applications

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