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Portable microcontroller-based electrostimulation system for nerve conduction studies

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Portable microcontroller-based electrostimulation system for nerve conduction studies

Content Provider	IET Digital Library
Author	Cossul, Sandra Andreis, Felipe Rettore Favretto, Mateus André Antonio, Afrânio de Castro Marques, Jefferson Luiz Brum
Abstract	Despite nerve conduction study (NCS) being an established procedure in the evaluation of neuromuscular disorders, its utility has been restrained by commercially available products or approaches presented in the literature that are either costly, physically large, dependent on specialised medical personnel to operate or targeted to specific conditions, evaluating only one or two nerves. Therefore, the objective of this work was to develop a point-of-care device for NCS that can be used to evaluate several nerves, yet is still portable, low-cost and easy to operate. The developed device is composed of three modules: (i) controller module and graphical user interface, responsible for system synchronisation and configuration, data management, graphical visualisation of the evoked action potential and stimulus voltage feedback (maximum error of 3.92%); (ii) stimulation module, which operates in a constant voltage mode and delivers a monophasic stimulus pulse with amplitudes between 0.84 and 230 V, with a discrete increment of 2.32 ± 0.64 V (mean ± SD) and duration of 100 or 200 µs; and (iii) data acquisition module, based on the ADS1298 front-end that records the evoked action potentials after the stimulus, with a sample rate of 16 or 32 kHz, 24-bit resolution and selectable voltage gain of 1 up to 12. Results demonstrated that the system could reliably deliver stimulation pulses through different loads (100 Ω, 1 kΩ and 10 kΩ) and accurately record data through frequencies of 10 Hz up to 10 kHz. Additionally, NCS of the ulnar motor nerve in a sample of healthy individuals showed that the device could effectively activate a peripheral nerve and record compound action potentials within normal limits established by the literature.
Starting Page	695
Ending Page	703
Page Count	9
ISSN	17518822
Volume Number	14
e-ISSN	17518830
Issue Number	Issue 6, Aug (2020)
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/iet-smt/14/6
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/10.1049/iet-smt.2019.0174
Journal	IET Science, Measurement & Technology
Publisher Date	2020-03-11
Access Restriction	Open
Rights Holder	© The Institution of Engineering and Technology
Subject Keyword	ADS1298 Front-end Bioelectric Potentials Bioelectric Signal Biology And Medical Computing Biomedical Equipment Constant Voltage Mode Controller Module Data Acquisition Data Acquisition Module Data Handling Technique Data Management Electrical Activity in Neurophysiological Processes Electrodiagnostics And Other Electrical Measurement Technique Evoked Action Potential External And Internal Data Communication, Nerve Conduction And Synaptic Transmission Frequency 10.0 Hz to 10 KHz Frequency 32.0 KHz Graphical User Interface Graphical Visualisation Medical Computing Microcontroller Monophasic Stimulus Pulse Nerve Conduction Neuromuscular Disorders Neuromuscular Stimulation Neurophysiology Peripheral Nerve Point-of-care Device Portable Microcontroller-based Electrostimulation System Record Data Sample Rate Specialised Medical Personnel Stimulation Module Stimulus Voltage Feedback Synchronisation System Synchronisation Time 200 Mus Time 200.0 Mus Ulnar Motor Nerve Voltage Gain
Content Type	Text
Resource Type	Article
Subject	Atomic and Molecular Physics, and Optics Electrical and Electronic Engineering

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
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