NDLI: Optical tracking of drug release from porous silicon delivery vectors

Content Provider	IET Digital Library
Author	Tonkin, James A. Shamsudeen, Sabeel Brown, Martyn Rowan Serda, Rita E. Rees, Paul Summers, Huw D.
Abstract	The controlled and sustained delivery of drugs to a specific location within the body is vitally important for effective treatment of chronic diseases such as cancer. One route in achieving this is to develop drug carrying systems from which release of the drug molecules can be controlled. In this study, the authors present characterisation measurements on such a system – porous silicon microparticles. The kinetic of release of the anti-cancer agent, doxorubicin is tracked in live, endothelial cells over a period of 24 h. The results are consistent with a release process of molecular diffusion from a fixed supply reservoir, with a characteristic release lifetime of 2 h. Detailed stochastic modelling of the diffusion process, mimicking the random walk of drug molecules within a heterogeneous size distribution of pores, provides an excellent fit to the data and indicates a doxorubicin diffusion constant of 2 × 10−11 m2s−1.
Starting Page	113
Ending Page	116
Page Count	4
ISSN	17518768
Volume Number	8
e-ISSN	17518776
Issue Number	Issue 2, Apr (2014)
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/iet-opt/8/2
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/10.1049/iet-opt.2013.0080
Journal	IET Optoelectronics
Publisher Date	2014-02-24
Access Restriction	Open
Rights Holder	© The Institution of Engineering and Technology
Subject Keyword	Anticancer Agent Biodiffusion Biological Transport Biology And Medical Computing Biomedical Imaging/measurement Biomedical Material Biomedical Optical Imaging Biomolecular Dynamics Cancer Cellular And Subcellular Transmembrane Physics Cellular Transport Characterisation Measurement Characteristic Release Lifetime Chronic Diseases Computer Vision And Image Processing Technique Controlled Drug Delivery Diffusion Process Doxorubicin Diffusion Constant Drug Carrying System Drug Delivery System Drug Molecule Random Walk Drug Molecule Release Drug Release Drugs Effective Treatment Endothelial Cell Fixed Supply Reservoir Heterogeneous Size Distribution Live Tracking Medical Image Processing Molecular Biophysics Molecular Diffusion Molecular Pattern Recognition Molecular Probes Optical And Laser Radiation Optical Tracking Optical, Image And Video Signal Processing Patient Care And Treatment Patient Diagnostic Method And Instrumentation Porous Material Porous Silicon Delivery Vector Porous Silicon MicroParticle Probability Theory Random Processes Release Kinetics Silicon Compound Statistics Stochastic Linearised SCUC Stochastic Modelling Sustained Drug Delivery Time 2 Hr
Content Type	Text
Resource Type	Article
Subject	Atomic and Molecular Physics, and Optics Electrical and Electronic Engineering

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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