NDLI: Biocompatibility assessment of SiO2–TiO2 composite powder on MG63 osteoblast cell lines for orthopaedic applications

Content Provider	IET Digital Library
Author	Chellappa, Maniickam Thejaswini, Bezawada Vijayalakshmi, Uthirapathy
Abstract	The objective of this study is to evaluate the biocompatibility of composite powder consisting of silica and titania (SiO2–TiO2) for biomedical applications. The advancement of nanoscience and nanotechnology encourages researchers to actively participate in reinvention of existing materials with improved physical, chemical and biological properties. Hence, a composite/hybrid material has given birth of new materials with intriguing properties. In the present investigation, SiO2–TiO2 composite powder was synthesised by sol-gel method and the prepared nanocomposite was characterised for its phase purity, functional groups, surface topography by powder X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy. Furthermore, to understand the adverse effects of composite, biocompatibility test was analysed by cell culture method using MG63 osteoblast cell lines as a basic screening method. From the results, it was observed that typical Si–O–Ti peaks in FT-IR confirms the formation of composite and the crystallinity of the composite powder was analysed by XRD analysis. Further in vitro biocompatibility and acridine orange results have indicated better biocompatibility at different concentrations on osteoblast cell lines. On the basis of these observations, we envision that the prepared silica–titania nanocomposite is an intriguing biomaterial for better biomedical applications.
Starting Page	77
Ending Page	82
Page Count	6
ISSN	17518741
Volume Number	11
e-ISSN	1751875X
Issue Number	Issue 1, Feb (2017)
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/iet-nbt/11/1
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/10.1049/iet-nbt.2016.0063
Journal	IET Nanobiotechnology
Publisher Date	2016-11-04
Access Restriction	Open
Rights Holder	© The Institution of Engineering and Technology
Subject Keyword	Acridine Orange Bioceramics Biocompatibility Test Biological Application Biological Property Biomaterial Synthesis Biomedical Application Biomedical Material Cell Culture Method Cellular Biophysics Ceramic Nanocomposite Chemical Property Composite-hybrid Materials Crystallinity Deposition from Liquid Phase (melts And Solutions) Energy Dispersive X-Ray Analysis Fourier Transform Infrared Spectra Fourier Transform Infrared Spectroscopy FT-IR Spectroscopy Functional Groups In Vitro Biocompatibility Infrared And Raman Spectra in Inorganic Crystal Inorganic SemiConductor And Insulator Intriguing Property Low-Dimensional Structure: Growth, Structure And Nonelectronic Property MG63 Osteoblast Cell Line Nanocomposite Nanofabrication Nanomedicine Nanoscience Nanotechnology Nanotechnology Application in Biomedicine Nanotoxicology Optical Property Orthopaedic Application Phase Purity Physical Property Powder X-Ray Diffraction Scanning Electron Microscopy Screening Method Silica-titania Nanocomposite Powder Silicon Compound SiO2-TiO2 Sol Gel Method Sol Gel Processing Solid Surface Structure Surface Property Surface Topography Titanium Compound X-Ray Chemical Analysis X-Ray Diffraction XRD
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Electronic, Optical and Magnetic Materials Electrical and Electronic Engineering Biotechnology

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