NDLI: Green synthesis of silver nanoparticles using Zingiber officinale and Thymus vulgaris extracts: characterisation, cell cytotoxicity, and its antifungal activity against Candida albicans in comparison to fluconazole

Content Provider	IET Digital Library
Author	Mohammadi, Mohsen Shahisaraee, Sabrieh Assadi Tavajjohi, Atiyeh Pournoori, Negin Muhammadnejad, Samad Mohammadi, Shahla Roodbar Poursalehi, Reza H, Hamid Delavari
Abstract	Fluconazole (FLZ) application as a highly successful commercial antifungal azole agent to treat the fungal infections is limited due to emergence of FLZ-resistant candida. In this study, the potential of green synthesised silver nanoparticles (NPs) as an antifungal agent against Candida albicans fungal pathogen is investigated. The extract of ginger (Zingiber officinale) and thyme (Thymus vulgaris) plays as reducing agent, capping agent and antifungal agent. The UV–visible spectroscopy shows the peak of surface plasmon resonance of synthesised Ag NPs after a period of time. The synthesised Ag NPs are spherical, with average sizes of 12 and 18 nm based on ginger and thyme extract, respectively. Fourier transform infrared spectroscopy confirms the adsorption of the plant extract on the surface of the as-prepared Ag NPs. Based on the minimum inhibitory concentration (MIC) method against Candida albicans, the antifungal activity of as-prepared green synthesised Ag NPs shows higher inhibitory in comparison to FLZ. Finally, the Ag NPs synthesised via thyme extract shows no cytotoxicity with concentration below 3.5 ppm, which can be considered as an appropriate candidate instead of FLZ to treat the superficial fungal infections.
Starting Page	114
Ending Page	119
Page Count	6
ISSN	17518741
Volume Number	13
e-ISSN	1751875X
Issue Number	Issue 2, Apr (2019)
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/iet-nbt/13/2
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/10.1049/iet-nbt.2018.5146
Journal	IET Nanobiotechnology
Publisher Date	2018-09-07
Access Restriction	Open
Rights Holder	© The Institution of Engineering and Technology
Subject Keyword	Adsorption Antibacterial Activity Antifungal Activity Antifungal Agent Antifungal Azole Agent Biomedical Material Candida Albicans Fungal Pathogen Cell Cytotoxicity Cellular Biophysics Diseases Fluconazole Application FLZ-resistant Candida Fourier Transform Infrared Spectra Fourier Transform Infrared Spectroscopy Ginger Green Synthesis Green Synthesised Silver NanoParticle Material Preparation Method of Preparation of Material Microorganisms Minimum Inhibitory Concentration Method Nanofabrication Nanomedicine Nanoparticle Nanotechnology Application in Biomedicine Nanotube And Nanostructured Material Particle Size Plant Extracts Silver Compound Structure of Solid Clusters Superficial Fungal Infections Surface Coating Surface Plasmon Polariton Propagation Property Thymus Vulgaris Extracts Ultraviolet Spectra UV-visible Spectroscopy Visible Spectra Zingiber Officinale
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Electronic, Optical and Magnetic Materials Electrical and Electronic Engineering Biotechnology

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