NDLI: Functional role of microRNA-500a-3P-loaded liposomes in the treatment of cisplatin-induced AKI

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Functional role of microRNA-500a-3P-loaded liposomes in the treatment of cisplatin-induced AKI

Content Provider	IET Digital Library
Author	Zhang, Suhua Sun, Huaixin Kong, Weixin Zhang, Bo
Abstract	Cisplatin treatment results in acute kidney injury (AKI) by the phosphorylation of mixed lineage kinase domain-like protein (MLKL). The knockout of MLKL, which is a principle mediator of necroptosis, is believed to alleviate the AKI symptoms. The present study was aimed to improve the therapeutic efficacy in AKI. For this purpose, miR-500a-3P was identified as appropriate miRNA therapeutics and loaded in liposome delivery carrier. The authors have showed that the miR-LIP directly controls the expression of RIPK3 and MLKL – a modulator of necroptosis and thereby reduces the severity of kidney injury. The miR-LIP significantly controlled the phosphorylation of MLKL compared to that of CDDP-treated HK2 cells. Similar results are observed with RIPK3. The miR-LIP has also been demonstrated to control the inflammatory response in tubular cells. Western blot analysis further revealed that the phosphorylation of P-65 was mainly responsible for the inflammatory response and miR-LIP significantly decreased the CDDP-induced NF-kB phosphorylation. Overall, the present study explored the molecular mechanism behind the necroptosis in AKI and potential of miRNA in targeting MLKL pathways. Study further highlights the potential advantage of liposome as a delivery carrier for miRNA therapeutics.
Starting Page	465
Ending Page	469
Page Count	5
ISSN	17518741
Volume Number	14
e-ISSN	1751875X
Issue Number	Issue 6, Aug (2020)
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/iet-nbt/14/6
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/10.1049/iet-nbt.2019.0247
Journal	IET Nanobiotechnology
Publisher Date	2020-03-16
Access Restriction	Open
Rights Holder	© The Institution of Engineering and Technology
Subject Keyword	Acute Kidney Injury AKI Symptoms Appropriate MiRNA Therapeutics Biochemistry Biomolecular Dynamics Biomolecular Interactions Biomolecular Structure, Configuration, Conformation, And Active Sites Cancer CDDP-induced NF-kB Cellular Biophysics Charge Transfer Complexes Cisplatin Treatment Result Cisplatin-induced AKI Current 500.0 A Drugs Enzymes Functional Role Genetics Inflammatory Response Injuries Interactions with Radiations at The Biomolecular Level Kidney Liposome Delivery Carrier Macromolecular Configuration (bonds, Dimensions) Medical Disorders MicroRNA-500a-3P-loaded Liposomes MiR-LIP Mixed Lineage Kinase Domain MLKL Pathways Molecular Biophysics Molecular Pattern Recognition Molecular Probes Necroptosis Patient Care And Treatment Patient Treatment Phosphorylation Physical Chemistry of Biomolecular Solutions And Condensed State Physics of Subcellular Structure RIPK3 Therapeutic Efficacy Toxicology
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Electronic, Optical and Magnetic Materials Electrical and Electronic Engineering Biotechnology

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Functional role of microRNA-500a-3P-loaded liposomes in the treatment of cisplatin-induced AKI