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A Portable Device Integrated with Aligned Carbon Nanotubes for Sensitive Virus Capture and Detection
| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | S. Zheng a. M. Terrones Y. Yeh H. Lu |
| Copyright Year | 2018 |
| Abstract | Point-of-care virus diagnosis is highly desirable in worldwide infectious disease control. Here we report a hand-held device for capturing viruses by applying physical size based exclusion inside a point-of-care device integrated with vertically aligned carbon nanotube (VACNT) nanostructures to achieve label-free and high throughput virus capture. The microfluidic device is constructed from a VACNT channel wall synthesized bottom-up via chemical vapor deposition (CVD). The VACNT has ~117 nm average gap size and ~97& porosity. By bonding with a polydimethylsiloxane (PDMS) cover sealing the top, the aqueous sample containing virus particles filter through the VACNT channel wall under negative pressure applied at the outlet end. We have demonstrated that the device is capable of filtering 50 μL of PBS containing ~6.3 × 104 counts of lentivirus particles in 10 minutes with 97& of capture efficiency, quantified by the cell infectious titration technique. |
| Starting Page | 6072 |
| Ending Page | 6075 |
| Page Count | 4 |
| File Format | HTM / HTML |
| ISBN | 9781538636466 |
| ISSN | 15584615 |
| Journal | 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) |
| DOI | 10.1109/EMBC.2018.8513515 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | C Fluorescence Carbon nanotubes Chemical vapour deposition Sensitive virus capture Point-of-care virus diagnosis High throughput virus capture Microorganisms Nanofabrication Microfabrication Capture efficiency Label-free virus capture Vertically aligned carbon nanotube nanostructures Aqueous sample Patient diagnosis Portable instruments Cell infectious titration technique Portable device Time 10.0 min Nanomedicine Point-of-care device Viruses (medical) Scanning electron microscopy Biomedical equipment Filtration Nanotube devices Worldwide infectious disease control Hand-held device Gap size VACNT channel wall Chemical vapor deposition BioMEMS Diseases CVD Numerical analysis Forestry Virus particles Physical size based exclusion Porosity Polydimethylsiloxane cover Cellular biophysics Microfluidics Microfluidic device |
| Content Type | Text |
| Resource Type | Preprint Article |
