NDLI: Comparative modeling studies of rat amiloride-sensitive cation channel 1, neuronal isoform b

Content Provider	IEEE Xplore Digital Library
Author	Noureen, N. Bano, R. Rashid, H.
Copyright Year	2009
Description	Author affiliation: Department of Bioinformatics, Mohammad Ali Jinnah University, Islamabad, Pakistan (Noureen, N.; Bano, R.; Rashid, H.)
Abstract	Acid-sensing ion channels (ASICs) of the epithelial sodium channel/degenerin (ENaC/DEG) gene family are protongated cation channels. ASICs have two transmembrane segments which are hydrophobic. Various proton-gated ion channels suggest that, ASIC and MDEG probably seems to be the first two members of this family and the genes for the new channels remain to be discovered. The presence of a large extracellular domain between two transmembrane alpha-helices and the short NH2 and COOH terminal cytoplasmic segments, characterizes these proteins. In order to relate the three-dimensional (3D) structure to their physiological function, channel proteins have been the focus of various computational approaches. On the basis of available X-ray structures, structural models of channels may be constructed by homology modeling. Here we present 3D structure of rat Amiloride-sensitive cation channel 1, neuronal isoform B through Comparative Modeling studies. Our studies will be useful in understanding the biochemical functions and interaction properties in detail.
Starting Page	162
Ending Page	167
File Size	875244
Page Count	6
File Format	PDF
ISBN	9781424456307
DOI	10.1109/ICET.2009.5353181
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-10-19
Publisher Place	Pakistan
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Sequences Humans alpha helices Predictive models Nervous system Extracellular FASTA format Proteins Application specific integrated circuits ASIC homology modeling Lungs beta strands Colon X-ray Bioinformatics 3D-structure
Content Type	Text
Resource Type	Article

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