NDLI: Liquid bead arrays meet multiplexing needs of clinical and research laboratories

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Conference, Emerging Information Technology 2005.

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Liquid bead arrays meet multiplexing needs of clinical and research laboratories

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Liquid bead arrays meet multiplexing needs of clinical and research laboratories

Content Provider	IEEE Xplore Digital Library
Author	Gibson, G.
Copyright Year	2005
Description	Author affiliation: Luminex Corp., Austin, TX, USA (Gibson, G.)
Abstract	Profile-oriented testing is becoming increasingly more important in both disease research and disease diagnosis. Research and clinical laboratories alike are expanding many single-analytic tests to include additional markers, as new data is uncovered. Technological innovations such as high-density arrays offer the promise of more efficient disease diagnosis and treatment. However, many of these promises remain unfulfilled. For example, the high-density array (/spl Gt/1000 features) is a powerful tool for research and discovery, but may not be suitable for a clinical laboratory due to complexity, inflexibility, poor reproducibility, and irrelevance of much of the data. Such challenges leave an unmet need in clinical laboratories for a simple, flexible, robust, and cost effective platform. An area of considerable promise is the medium-density array (<1000 features), which allows more cost-effective, focused panels of assays to be performed. Specifically, medium-density liquid bead arrays further address the issues of inflexibility and lack of reproducibility that plague two-dimensional arrays. With standard tests such as cytokines, cystic fibrosis, autoimmune, cytochrome P450, and HLA testing all falling into the medium-density range of multiplexing, liquid bead arrays address many current laboratory needs.
File Size	107689
File Format	PDF
ISBN	0780393287
DOI	10.1109/EITC.2005.1544371
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2005-08-15
Publisher Place	Taiwan
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Drugs Costs Automatic testing Laboratories Planar arrays Throughput Reproducibility of results Robustness Gene expression Diseases
Content Type	Text
Resource Type	Article

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