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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Roy, R. Wenjin Chen Goodell, L.A. Jun Hu Foran, D.J. Desai, J.P. |
| Copyright Year | 2010 |
| Description | Author affiliation: Department of Pathology and Laboratory Medicine, Robert Wood Johnson Medical School NJ-08903-2681 USA (Goodell, L.A.) || Center for Biomedical Imaging and Informatics (CBII) at the Cancer Insitute of New Jersey, New Brunswick, 08903-2681 USA (Wenjin Chen; Jun Hu) || Center for Biomedical Imaging and Informatics (CBII) at the Cancer Insitute of New Jersey, 08903-2681 USA (Foran, D.J.) || Robotics, Automation, and Medical Systems (RAMS) Laboratory, Maryland Robotics Center, Institute for Systems Research at the University of Maryland, College Park MD 20742 USA (Desai, J.P.) || Robotics, Automation, and Medical Systems (RAMS) Laboratory at the University of Maryland, College Park MD 20742 USA (Roy, R.) |
| Abstract | Much of the difficulty in rendering consistent evaluation of pathological tissue specimens arises from qualitative impressions of observers. Hence, a quantitative phenotype to automatically characterize the type and stage of cancer based upon an objective measure of its morphology and mechanical properties could provide insight regarding the changes that occur in the tissue environment during the course of disease onset and progression. In this work, we attempt to evaluate the elastic modulus of normal and cancerous human breast tissue using Atomic Force Microscopy (AFM), which consists of a micro-cantilever that probes the sample at multiple locations to evaluate its local stiffness. We use the Hertz contact model to evaluate the elastic modulus values. Our initial findings show that cancerous specimens exhibit significantly lower elastic modulus than normal breast tissue. |
| Starting Page | 710 |
| Ending Page | 715 |
| File Size | 425779 |
| Page Count | 6 |
| File Format | |
| ISBN | 9781424477081 |
| ISSN | 21551782 |
| e-ISBN | 9781424477098 |
| DOI | 10.1109/BIOROB.2010.5625952 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2010-09-26 |
| Publisher Place | Japan |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Atomic force microscopy Force Breast tissue Cancer Biomedical imaging |
| Content Type | Text |
| Resource Type | Article |
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