Please wait, while we are loading the content...
| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Conti, V. Lanza, B. Sorbello, F. Vitabile, S. |
| Copyright Year | 2010 |
| Abstract | The main objective of this work is to analyze metabolic networks evolution in terms of their robustness and fault tolerance capabilities. In metabolic networks, errors can be seen as random removal of network nodes, while attacks are high-connectivity-degree node deletion aimed at compromising network activity. This paper proposes a software framework, namely BioAnalysis, used to test the robustness and the fault tolerance capabilities of real metabolic networks, when mutations and node deletions affect the network structure. The performed simulations are related to the central metabolic network of the well-known E. coli single-celled bacterium and involve either hub nodes or non-hub nodes, whose influence on the network robustness and activity is different. The performed trials have shown that the node connectivity degree as well as the node functional role in the network are key issues to evaluate the impact of node deletion on network robustness and activity. With more details, functional analysis has demonstrated that low-connectivity-degree nodes may drastically influence the normal behaviour of the network, while high-connectivity-degree nodes may produce soft failure in network operations. The results coming from described simulations have been confirmed by similar in vivo laboratory tests on real cluster of E. Coli bacteria. |
| Starting Page | 138 |
| Ending Page | 145 |
| File Size | 883033 |
| Page Count | 8 |
| File Format | |
| ISBN | 9781424459179 |
| e-ISBN | 9781424459186 |
| DOI | 10.1109/CISIS.2010.136 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2010-02-15 |
| Publisher Place | Poland |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Software testing Performance evaluation Genetic mutations Laboratories E. coli properties analysis Metabolic networks Biochemistry Functional analysis Fault tolerance In vivo Microorganisms hub and non-hub nodes Robustness network robustness |
| Content Type | Text |
| Resource Type | Article |
National Digital Library of India (NDLI) is a virtual repository of learning resources which is not just a repository with search/browse facilities but provides a host of services for the learner community. It is sponsored and mentored by Ministry of Education, Government of India, through its National Mission on Education through Information and Communication Technology (NMEICT). Filtered and federated searching is employed to facilitate focused searching so that learners can find the right resource with least effort and in minimum time. NDLI provides user group-specific services such as Examination Preparatory for School and College students and job aspirants. Services for Researchers and general learners are also provided. NDLI is designed to hold content of any language and provides interface support for 10 most widely used Indian languages. It is built to provide support for all academic levels including researchers and life-long learners, all disciplines, all popular forms of access devices and differently-abled learners. It is designed to enable people to learn and prepare from best practices from all over the world and to facilitate researchers to perform inter-linked exploration from multiple sources. It is developed, operated and maintained from Indian Institute of Technology Kharagpur.
Learn more about this project from here.
NDLI is a conglomeration of freely available or institutionally contributed or donated or publisher managed contents. Almost all these contents are hosted and accessed from respective sources. The responsibility for authenticity, relevance, completeness, accuracy, reliability and suitability of these contents rests with the respective organization and NDLI has no responsibility or liability for these. Every effort is made to keep the NDLI portal up and running smoothly unless there are some unavoidable technical issues.
Ministry of Education, through its National Mission on Education through Information and Communication Technology (NMEICT), has sponsored and funded the National Digital Library of India (NDLI) project.
| Sl. | Authority | Responsibilities | Communication Details |
|---|---|---|---|
| 1 | Ministry of Education (GoI), Department of Higher Education |
Sanctioning Authority | https://www.education.gov.in/ict-initiatives |
| 2 | Indian Institute of Technology Kharagpur | Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project | https://www.iitkgp.ac.in |
| 3 | National Digital Library of India Office, Indian Institute of Technology Kharagpur | The administrative and infrastructural headquarters of the project | Dr. B. Sutradhar bsutra@ndl.gov.in |
| 4 | Project PI / Joint PI | Principal Investigator and Joint Principal Investigators of the project |
Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon |
| 5 | Website/Portal (Helpdesk) | Queries regarding NDLI and its services | support@ndl.gov.in |
| 6 | Contents and Copyright Issues | Queries related to content curation and copyright issues | content@ndl.gov.in |
| 7 | National Digital Library of India Club (NDLI Club) | Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach | clubsupport@ndl.gov.in |
| 8 | Digital Preservation Centre (DPC) | Assistance with digitizing and archiving copyright-free printed books | dpc@ndl.gov.in |
| 9 | IDR Setup or Support | Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops | idr@ndl.gov.in |
|
Loading...
|