NDLI: Study of Pentoxifylline Chemical Stability from Modified Release Tablets with Hydrophilic Mould

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2008 First International Conference on Complexity and Intelligence of the Artificial and Natural Complex Systems. Medical Applications of the Complex Systems. Biomedical Computing

Table of contents

Preface

Conference Committee

list-reviewer

Modeling of Social Transitions Using Intelligent Systems

Semantic Web-Based Knowledge Management in Distributed Systems

Complex Mobile Multiagent Systems

Trajectory Errors of the 6-PGK Parallel Robot

An Agile MDA Approach for the Development of Service-Oriented Component-Based Applications

Geometrical Method for Description of the 6-PGK Parallel Robot's Workspace

Genetic Algorithms: A Decision Tool in Industrial Disassembly

A New Approach for Detecting Intrusions Using Jordan/Elman Neural Networks

A Certain Complexity Threshold during Growth of Functioning Networks

Network Classes and Graph Complexity Measures

A Heuristic Chaotic Neural Network: Candidate Model for Perception

Towards a Channel Capacity of Communication Networks

Applications of Principal Components Methods

Modified Advanced Image Coding

Some Improvements of t-Cherry Junction Trees

A Multidimensional Data Model for Analysis of Agricultural Soil Characteristics

Cryptanalysis of KSAm-like Algorithms

Essential Graphs and Bayesian Networks

Clustering Based on Context Similarity

On Certain Continued Fraction Representations of Poly-basic Series

Risk Aversion through Fuzzy Numbers

IMASC - An Intelligent MultiAgent System for Clinical Decision Support

Supramolecular Assemblies of Functional Nanoporphyrins in Therapeutics

Graphical Representation of the Pandemic Spreading

Selection of Target Area for Interventional and Cell Therapy after Myocardial Infarction Using 3d Echocardiography

Specific Movement Detection in EEG Signal Using Time-Frequency Analysis

Regional Networking for Decreasing Mortality in Acute Coronary Syndromes on a Target Population of 1 Million Inhabitants

Simulation of the Growth Process of a Silicium Nanotubes Structure as Biomaterial in the Porozity of Zeolite AFI

Study of Pentoxifylline Chemical Stability from Modified Release Tablets with Hydrophilic Mould

Models for the Respiratory System Using Morphology-Based Electrical Analogy

Author index

Study of Pentoxifylline Chemical Stability from Modified Release Tablets with Hydrophilic Mould

Content Provider	IEEE Xplore Digital Library
Author	Mircia, E. Imre, S. Sipos, E. Avrigeanu, V. Popovici, A. Hancu, G.
Copyright Year	2008
Description	Author affiliation: Dept. of Drug Anal., Univ. of Med. & Pharmacy, Targu Mures, Romania (Imre, S.) \|\| Dept. of Pharm. Technol., Univ. of Med. & Pharmacy, Targu Mures, Romania (Sipos, E.; Popovici, A.) \|\| Dept. of Pharm. Chem., Univ. of Med. & Pharmacy, Targu Mures, Romania (Hancu, G.) \|\| Dept. of Org. Chem., Univ. of Med. & Pharmacy, Targu Mures, Romania (Mircia, E.; Avrigeanu, V.)
Abstract	Thermal and chemical stability of pentoxifylline from modified release tablets were studied. This experimental study observed the influence of temperature and humidity on the stability of pentoxifylline from the proposed formulations. The paper describes the HPLC determination of pentoxifylline from new controlled release tablets with hydrophilic matrix (HPMC, HPC, HEC). A C18 column with a mobile phase containing water : acetonitrile 70:30 (V/V) and UV detection at 280 nm was used. The "in vitro" dissolution test was carried out regarding the officinal stipulations of USP; the machine nr.2 was used (with paddles); as dissolution environment 1000 ml water, a constant temperature of 37 plusmn 0.5degC was kept. In all experiences, the rotation speed was 50 rpm. The studied tablets were kept in the stability chamber at a temperature of 40 plusmn 2degC and a relative humidity of 75 plusmn 5%. At different time intervals (a month, three months, six months), samples were prelevated to accomplish the dissolution test and the quantitative determination of pentoxifylline. From the evaluation of the experimental results, we observed the stability of pentoxifylline from all the prepared tablets.
Starting Page	231
Ending Page	242
File Size	497973
Page Count	12
File Format	PDF
ISBN	9780769536217
DOI	10.1109/CANS.2008.35
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2008-11-08
Publisher Place	Romania
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Temperature Chemical analysis Alcoholism hydrophillic matrix Stability analysis Thermal stability Chemical technology high-pressure liquid chromatography Chemistry medical informatics Humidity pentoxifylline Organic chemicals stability Testing
Content Type	Text
Resource Type	Article

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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The use of phospholipid modified column for the determination of lipophilic properties in high performance liquid chromatography.

Effects of Storage Humidity on the Mechanical, Microstructural, and Drug Release Properties of Hydroxypropylmethylcellulose-Based Hydrophilic Matrix Tablets

A revisit to the retention mechanism of hydrophilic interaction liquid chromatography using model organic compounds.

Telmisartan Tablets Repackaged into Dose Administration Aids: Physicochemical Stability under Tropical Conditions

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Study of Pentoxifylline Chemical Stability from Modified Release Tablets with Hydrophilic Mould

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