NDLI: Preparation and characterization of natural polymer-based composite films for hard tissue engineering approaches

Content Provider	IEEE Xplore Digital Library
Author	Işıklı, C. Endoğan, T. Kızıltay, A. Hasırcı, V. Hasırcı, N.
Copyright Year	2010
Description	Author affiliation: ODTÜ, BIOMAT, Biyomedikal Mühendisligi Bölümü, 06531, Ankara, Türkiye (Işıklı, C.; Hasırcı, V.; Hasırcı, N.) \|\| ODTÜ, BIOMAT, Biyoteknoloji Bölümü, 06531, Ankara, Türkiye (Kızıltay, A.) \|\| ODTÜ, BIOMAT, Polimer Bilimi ve Teknolojisi Bölümü, 06531, Ankara, Türkiye (Endoğan, T.)
Abstract	Hard tissue engineering has emerged to compensate for the losses in the properties of damaged bones by using scaffolds and cells. In this study, natural polymers chitosan and gelatin were used as scaffold materials because of their great resemblance to extracellular matrix elements. To enhance the mechanical properties and osteoconductivity of structures hydroxyapatite was added. This study is about the characterization of physico-chemical properties and cell behavior on scaffolds to optimize chitosan-gelatin ratio and aims to assess the effects of hydroxyapatite addition into polymeric matrix. According to thermal test results, decomposition temperatures decreased with non-sintered hydroxyapatite (nsHA) addition. Mechanical test results of composite structures were similar to that of cortical bone. Chitosan-gelatin films prepared with same amount of polymers showed the highest swelling degree. While nsHA added pure chitoan films showed higher cell number with respect to chitosan films; on the contrry, chitosan-gelatin polymeric blends indicated an opposite trend after nsHA addition.
Starting Page	1
Ending Page	2
File Size	576427
Page Count	2
File Format	PDF
ISBN	9781424463800
e-ISBN	9781424463824
DOI	10.1109/BIYOMUT.2010.5479749
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-04-21
Publisher Place	Turkey
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Tissue engineering Polymer gels Thermal decomposition Polymer films Bones Mechanical factors Matrix decomposition Extracellular Testing Biological materials
Content Type	Text
Resource Type	Article

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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