NDLI: Application of SELDI technique: Salivary protein fingerprint spectrum in the diagnosis of thyroid cancer

Content Provider	IEEE Xplore Digital Library
Author	Sun Kehuan Cao Meiqun Wu Zhengzhi Li Lujun
Copyright Year	2012
Description	Author affiliation: The Second Clinical Medical College, Ji'nan University, Shenzhen Geriatric Research Institute, Guangdong Province, China (Sun Kehuan; Cao Meiqun; Wu Zhengzhi; Li Lujun)
Abstract	Objective: Using surface-enhanced laser desorption/ionization (SELDI) mass spectrometry to test the salivary protein fingerprint from the patients with thyroid cancer, benign nodular goiter and healthy subjects, to screen out the differentially expressed proteins between each group, and establish a diagnostic model with the help of bioinformatics to provide a novel approach for the early diagnosis of thyroid cancer. Methods: Saliva protein fingerprints of 49 patients with thyroid cancer, 34 patients with nodular goiter and 43 healthy subjects were tested using SEDLI technique. Specific differentially expressed proteins in the saliva of thyroid cancer patient were screened out and a diagnostic model was established with the help of bioinformatics. Results: The total accuracy of the cross validation (test group) for the diagnostic model of thyroid cancer and health control was 81.8% (72/88), sensitivity 88.9% (40/45), specificity 74.4% (32/43); The total accuracy of the cross validation (test group) for the diagnostic model of thyroid cancer and nodular goiter was 89.1% (74/83), sensitivity 87.7%(43/49), specificity 91.1% (31/34). Conclusions: By using SELDI technique, a preliminary diagnostic model for thyroid cancer was established, which may provide a novel approach of high sensitivity and strong specificity for the early diagnosis and pre-operation diagnosis of thyroid cancer. It deserves further investigation and application.
Starting Page	664
Ending Page	668
File Size	489408
Page Count	5
File Format	PDF
ISBN	9781467321099
e-ISBN	9781467321082
DOI	10.1109/ITiME.2012.6291392
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-08-03
Publisher Place	Japan
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	saliva protein finger print Companies surface enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) thyroid cancer diagnostic model Bioinformatics Biomedical monitoring Monitoring
Content Type	Text
Resource Type	Article

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