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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Said, H.M. |
| Copyright Year | 2013 |
| Description | Author affiliation: Dept. of Radiat. Oncology, Univ. of Wurzburg, Wurzburg, Germany (Said, H.M.) |
| Abstract | The hypoxia-inducible enzyme carbonic anhydrase IX (CA-IX) is considered as a surrogate marker of tumor hypoxia, prognosis indicator and a potential the expression pattern of the human tumor hypoxia marker gene CA-IX protein, CA9-mRNA and hypoxia-inducible factor-In (HIF-1α) protein levels in GaMG cells exposed to in vitro hypoxia (1, 6 or 24 h at 5%, 1 % or 0.1 % 02). All cell lines displayed a strong hypoxic induction of CA9-mRNA in response to prolonged severe hypoxia with cell-line specific patterns at moderate to mild hypoxia and shorter treatment times. In GaMG cell lines, a marked induction of CA-IX protein in response to severe hypoxia was seen. CA-IX over expression was paralleled by the results for HIF-1α protein. CA-IX expression pattern in human malignant glioblastoma cells (GBM) resulted from low oxygen concentrations or constitutive, oncogene-related, over expression is considered prognostically relevant. |
| Sponsorship | IEEE Syst., Man Cybern. Soc. |
| Starting Page | 403 |
| Ending Page | 407 |
| File Size | 450539 |
| Page Count | 5 |
| File Format | |
| ISBN | 9781467329705 |
| e-ISBN | 9781467329712 |
| DOI | 10.1109/ICCME.2013.6548278 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2013-05-25 |
| Publisher Place | China |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Proteins Human Brain Tumor Marker RNA Loading Results Discussion and Conclusions In vitro Materials and Methods Cancer Tumors Immune system |
| Content Type | Text |
| Resource Type | Article |
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