NDLI: Non-invasive detecting cerebral hemoglobin concentration of newborns during oxygen inhalation using near-infrared spectroscopy

Content Provider	IEEE Xplore Digital Library
Author	Teng Yichao Li Yue Hou Xinlin
Copyright Year	2011
Description	Author affiliation: Department of Pediatrics, Peking University First Hospital, Beijing 100034, China (Hou Xinlin) \|\| Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China (Teng Yichao; Li Yue)
Abstract	Human tissue oxygenation status can be completely described by the absolute values of the tissue hemoglobin concentrations. To detect them non-invasively and conveniently using continuous-wave near infrared spectroscopy (NIRS), the “in vivo calibration” algorithm was adopted. Three newborns were discussed during oxygen inhalation. By comparing the absorption coefficient before and after the change of tissue oxygenation induced by oxygen inhalation, the cerebral reduced scattering coefficient was calculated when the correlation coefficient R was above 0.75. Then the cerebral oxy- and deoxy-hemoglobin concentrations were derived based on the solution of steady-state diffusion equation. The total hemoglobin concentration of brain tissue was 50.1±6.1µM, which was consistent with most of the recent reports. In summary, even though further discussions are needed, the “in vivo calibration” method is effective and relatively accurate to detect human tissue hemoglobin concentrations.
Starting Page	121
Ending Page	126
File Size	618754
Page Count	6
File Format	PDF
ISBN	9781424493234
e-ISBN	9781424493241
DOI	10.1109/ICCME.2011.5876716
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-05-22
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	hemoglobin concentration Extrapolation absorption coefficient Instruments Fitting reduced scattering coefficient Detectors Near-infrared spectroscopy (NIRS) oxygen Blood
Content Type	Text
Resource Type	Article

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