NDLI: The boston retinal prosthesis: A 15-channel hermetic wireless neural stimulator

Content Provider	IEEE Xplore Digital Library
Author	Kelly, S.K. Shire, D.B. Doyle, P. Gingerich, M.D. Drohan, W.A. Rizzo, J.F. Theogarajan, L.S. Jinghua Chen Cogan, S.F. Wyatt, J.L.
Copyright Year	2009
Description	Author affiliation: Massachusetts Institute of Technology, Cambridge, MA, USA (Cogan, S.F.) \|\| EIC Laboratories, Norwood, MA USA (Jinghua Chen) \|\| Boston VA Healthcare System, Boston, MA, USA (Kelly, S.K.; Shire, D.B.; Doyle, P.; Gingerich, M.D.; Drohan, W.A.; Rizzo, J.F.) \|\| Massachusetts Eye and Ear Infirmary, Boston, MA USA (Theogarajan, L.S.)
Abstract	A miniaturized, hermetically-encased, wirelessly-operated retinal prosthesis has been developed for pre-clinical studies in Yucatan minipig animal models. The prosthesis attaches conformally to the outside of the eye and drives a microfabricated thin-film polyimide stimulating electrode array with sputtered iridium oxide electrodes. This array is implanted in the subretinal space using a specially-designed ab externo surgical technique that uses the retina to hold the array in place while leaving the bulk of the prosthesis outside the eye. The implanted device includes a hermetic titanium case containing a 15-channel stimulator chip and discrete circuit components. Feedthroughs from the case connect to secondary power- and data-receiving coils. In addition, long-term in vitro pulse testing was performed on the electrodes to ensure that their lifetime would match that of the hermetic case. The final assembly was tested in vitro to verify wireless operation of the system in biological saline using a custom RF transmitter circuit and primary coils. Stimulation pulse strength, duration and frequency were programmed wirelessly using a custom graphical user interface. Operation of the retinal implant has been verified in vivo in two pigs for up to five and a half months by measuring stimulus artifact on the eye surface using a contact lens electrode.
Starting Page	1
Ending Page	6
File Size	1522189
Page Count	6
File Format	PDF
ISBN	9781424446407
DOI	10.1109/ISABEL.2009.5373638
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-11-24
Publisher Place	Slovakia
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Coils biomedical engineering bioelectric potentials Retina Circuit testing In vitro Sputtering Electrodes iridium Animals Surgery neuromuscular stimulation integrated circuit design Polyimides telemetry biomedical electrodes Neural prosthesis
Content Type	Text
Resource Type	Article

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