NDLI: Partial profile alignment kernels for protein classification

Content Provider	IEEE Xplore Digital Library
Author	Thanh Ngo Rui Kuang
Copyright Year	2009
Description	Author affiliation: Department of Computer Science and Engineering, University of Minnesota, Twin Cities, 200 Union Street SE, Minneapolis, 55455, USA (Thanh Ngo; Rui Kuang)
Abstract	Remote homology detection and fold recognition are the central problems in protein classification. In real applications, kernel algorithms that are both accurate and efficient are required for classification of large databases. We explore a class of partial profile alignment kernels to be used with support vector machines (SVMs) for remote homology detection and fold recognition. While existing profile-based kernels use the whole profiles to determine the similarity between pairs of proteins, the partial profile alignment kernels are derived from part of the position specific scoring matrices (PSSMs) in the profiles for alignment. Specifically, at each position in the PSSM, only amino acids in the mutation neighborhood of the corresponding amino acid in the original protein sequence are considered for alignment to remove noise and improve computing efficiency. Our experiments on SCOP bench datasets show that the partial profile alignment kernels achieved overall better classification results for both fold recognition and remote homology detection than profile kernels and profile-alignment kernels. In addition, our algorithm using only a fraction of the profiles saves the cost of computing the kernels significantly, compared to the full-profile alignment methods.
Starting Page	1
Ending Page	4
File Size	144376
Page Count	4
File Format	PDF
ISBN	9781424447619
DOI	10.1109/GENSIPS.2009.5174328
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-05-17
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Computer science Protein engineering Databases Genetic mutations Hidden Markov models Amino acids Frequency Protein sequence Matrices Kernel
Content Type	Text
Resource Type	Article

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