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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Jiang Wu Ying-qiang Guo Guang-fu Yin Huai-qing Chen Yunqing Kang |
| Copyright Year | 2008 |
| Description | Author affiliation: Coll. of Mater. Sci. & Eng., Sichuan Univ., Chengdu (Jiang Wu) |
| Abstract | Success in bone implant depends greatly on the composition and surface features of the implant. The surface-modification measures not only favor implant's osteoconductivity, but promote both bone anchoring and biomechanical stability. This paper reports an approach to combine a hydroxyapatite(HA) coated substrate with a cellular vehicle for delivery of bone morphogenetic protein-2 (BMP-2) so that synergistically enhancing the osteoconductivity of implant surfaces. First, we examined the in vitro attachment growth and osteoinductive activity of transfected BMP-producing bone marrow mesenchymal stem cells(BMSCs) on a plasma sprayed HA coated substrate. Second, the osteointegrate efficacy of the combined method of BMP-2 gene delivery and HA coated scaffold in vivo was evaluated using a rat model. It was found that the HA coated substrate could allow the attachment and growth of BMP-2 transfected BMSCs, and this combined application synergistically augmented osteoinductive ability of the substrate surface . In vivo, the HA coated substrates successfully functioned as a surface enhancement plate for bioactive BMP-2 release, as they both elevated bone anchoring and biomechanical stability in a rat model. |
| Starting Page | 755 |
| Ending Page | 759 |
| File Size | 1285486 |
| Page Count | 5 |
| File Format | |
| ISBN | 9780769531182 |
| DOI | 10.1109/BMEI.2008.85 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2008-05-27 |
| Publisher Place | China |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Plasma-sprayed Coatings Vehicles Osteoconductivity Proteins In vivo Stem cells Implants Plasma stability Bones Plasma measurements Thermal spraying Mesenchymal stem cells |
| Content Type | Text |
| Resource Type | Article |
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