NDLI: A continuum computational model of mitotic matrix formation

Content Provider	IEEE Xplore Digital Library
Author	Changji Shi Channels, W.E. Yixian Zheng Iglesias, P.A.
Copyright Year	2011
Description	Author affiliation: Carnegie Institution of Washington, Department of Embryology, Baltimore, MD 21218, USA (Yixian Zheng) \|\| Johns Hopkins University, Department of Electrical and Computer Engineering, Baltimore, MD 21218, USA (Changji Shi; Channels, W.E.; Iglesias, P.A.)
Abstract	Mitotic spindle assembly and chromosome segregation are dynamic processes that require microtubules (MTs), MT-associated motors, MT-binding proteins, and chromosomes to coordinate with each other. Because of the complexity of the system, a thorough understanding of the principles that govern mitotic spindle formation remains elusive. Computational models in biology present an attractive tool to deal with complexity, allowing testing of different hypotheses. Here we developed a computational spatially heterogeneous model of known biochemical interactions involved in spindle formation. Using this model, we investigate the effect that individual species have on spindle morphology and chromosome segregation. Finally, we show the impact that Lamin B, thought to be a component of the long-sought-after spindle matrix, has on spindle formation during mitosis.
Starting Page	1
Ending Page	5
File Size	1252525
Page Count	5
File Format	PDF
ISBN	9781424498468
e-ISBN	9781424498482
e-ISBN	9781424498475
DOI	10.1109/CISS.2011.5766243
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-03-23
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Computational modeling Mathematical model Polymers Biological cells Assembly Equations Radio access networks
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

A blade element actuator disc approach applied to tidal stream turbines

Large Eddy Simulation of the Internal Flow in Diesel Nozzles

An efficient and fast calculation method of wall distance for hybrid-unstructured grids

Recent advances in mesh-based modeling of individual cells in biological fluids

Preliminary turbulence model validation for flow across rotating cylinders using ANSYS CFX

A separate-SMDP approximation technique for RRM in heterogeneous wireless networks

Some optimizations of the Galerkin-Bubnov Integral Boundary Element Method

Mathematical modeling and simulation for keloid scars formation from the prosthetic blunt socket

Mathematical modeling of two case of biological mobility

A continuum computational model of mitotic matrix formation

Similar Documents

A blade element actuator disc approach applied to tidal stream turbines

Large Eddy Simulation of the Internal Flow in Diesel Nozzles

An efficient and fast calculation method of wall distance for hybrid-unstructured grids

Recent advances in mesh-based modeling of individual cells in biological fluids

Preliminary turbulence model validation for flow across rotating cylinders using ANSYS CFX

A separate-SMDP approximation technique for RRM in heterogeneous wireless networks

Some optimizations of the Galerkin-Bubnov Integral Boundary Element Method

Mathematical modeling and simulation for keloid scars formation from the prosthetic blunt socket

Mathematical modeling of two case of biological mobility

A continuum computational model of mitotic matrix formation