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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Jui-Ming Chen Meng-Hsiun Tsai Shih-Huei Wang Sheng-Hsiung Chiu |
| Copyright Year | 2011 |
| Description | Author affiliation: Institute of Genomics and Bioinformatics, National Chung Hsing University Taiwan, R.O.C (Shih-Huei Wang) || Department of Endocrinology and Metabolism, Tungs' Taichung MetroHarbor Hospital Taiwan, R.O.C (Jui-Ming Chen) || Troilus Biotechnology Co., Ltd, Taiwan (Sheng-Hsiung Chiu) || Department of Management Information Systems, National Chung Hsing University Taiwan, R.O.C (Meng-Hsiun Tsai) |
| Abstract | In the current cancer research field, microarray is one of the most commonly used tools. It has the advantage of containing a large amount of data, which helped us in recording gene expressions in cancer and comparing the difference between normal cells and cancer cells. However, contemporary cancer research does not have a positive definition in how to analyze the microarray data. In this essay, we utilize the microarray data from the carcinoma cancer as primary sample. And we apply statistical methods and mathematical calculations to establish a diseases analyzing model. At first, we use principal component analysis to process the pre-selected data. Then we use ANOVA to select the genes with significant expression differences to be our target genes. Finally we use supervised learning method to evaluate the accuracy of classification. This analytical model helps to reduce the number of incorrect attempts and cut down the time which has to be spent in experiments. This model can analyze complicated cancer expression data, and it can also be useful in researches for other diseases. |
| Starting Page | 1638 |
| Ending Page | 1642 |
| File Size | 432390 |
| Page Count | 5 |
| File Format | |
| ISBN | 9781612841809 |
| e-ISBN | 9781612841816 |
| DOI | 10.1109/FSKD.2011.6019914 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2011-07-26 |
| Publisher Place | China |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Gene regulator network Accuracy Analysis of Variance Supervised learning Gene expression Decision trees Analysis of variance Cancer Principal component analysis Tumors |
| Content Type | Text |
| Resource Type | Article |
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