NDLI: Deducing Causal Relationships among Different Histone Modifications, DNA Methylation and Gene Expression

Content Provider	IEEE Xplore Digital Library
Author	Yunfeng Qi Yan Zhang Jie Lv Hongbo Liu Jiang Zhu Jianzhong Su
Copyright Year	2009
Abstract	Histone modifications and DNA methylation are two major epigenetic factors regulating gene expression. However, the mechanism in which DNA methylation and histone modifications co-regulate gene expression was little studied. In our study, classifications of DNA methylaion and gene expression showed the complicated relationship between gene expression and epigenetic factors. A Bayesian network was constructed by using the high-resolution maps of histone modifications, DNA methylation and gene expression in human CD4+ T cells to deduce causal and combinatorial relationships among them. PolII was found as the only direct regulator to gene expression, which was not found in prior studies. Our Bayesian network showed that epigenetic factors such as H3K4me3, H3K27me3 and DNA methylation are key regulators of gene expression, though indirectly. However they were considered to combinatorially stabilize the state and structure of chromatin.
Starting Page	139
Ending Page	143
File Size	896492
Page Count	5
File Format	PDF
ISBN	9780769537368
DOI	10.1109/ICNC.2009.606
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-08-14
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Regulators Humans Genomics Educational institutions Histone Modifications Gene expression Chromosome mapping Bayesian methods Biological processes DNA methylation Bioinformatics Bayesian network gene expression DNA computing
Content Type	Text
Resource Type	Article

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