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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Pei Chen Shuoyang Qiu Yue Wang Yongjun Li |
| Copyright Year | 2015 |
| Description | Author affiliation: Sch. of Comput. Sci. & Eng., South China Univ. of Technol., Guangzhou, China (Pei Chen; Yongjun Li) || Stanford Univ., Stanford, CA, USA (Yue Wang) || Sch. of Eng., Univ. of Edinburgh, Edinburgh, UK (Shuoyang Qiu) |
| Abstract | Identifying the pre-transition state just before the occurrence of a critical transition during a complex biological process is a challenging task, because the state of the system may show little apparent change or clear phenomenon before this critical transition during the biological processes. By regarding that the pre-transition state is the end or change-point of a stationary Markov process, we present a novel computational method, hidden Markov model (HMM) based state-transition forward method, which is a non-parametric estimation and can identify the pre-transition state. To validate the effectiveness, we apply this method to detect the signal of the imminent critical deterioration of complex diseases based on both simulated dataset and the rich information provided by high-throughput microarray data. We identify the pre-transition states and a number of related modules for the acute lung injury triggered by phosgene inhalation. Both functional and pathway enrichment analyses validate the results. |
| Sponsorship | IEEE |
| Starting Page | 555 |
| Ending Page | 562 |
| File Size | 801307 |
| Page Count | 8 |
| File Format | |
| e-ISBN | 9781467367998 |
| DOI | 10.1109/BIBM.2015.7359743 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2015-11-09 |
| Publisher Place | USA |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | catastrophic deterioration pre-transition state Hidden Markov models Markov processes Bifurcation complex disease hidden Markov model (HMM) Yttrium IP networks critical transition |
| Content Type | Text |
| Resource Type | Article |
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