NDLI: DNAjig: A New Approach for Building DNA Nanostructures

Content Provider	IEEE Xplore Digital Library
Author	Haque, M.M. Kalyanaraman, A. Dhingra, A. Abu-Lail, N. Graybeal, K.
Copyright Year	2009
Abstract	DNA self-assembly is an emerging technique in DNA nanotechnology that holds promise for high impact applications such as in the synthesis of DNA-based nanodevices in medicine, robotics and electronics. Recent advancements in technologies and ideas have spurred new growth in the area. The most significant challenge faced by designers in the field is the lack of algorithmic and software options to aid in the design process, and as a result the scope of synthesis has been restricted to modeling a limited set of shapes in 2D. In this paper, we propose a new design methodology called DNAjig to build DNA nanostructures. The highlights of this method are as follows: i) The construction procedure is based on a novel application of space-filling curves to model the shape of an arbitrary user-specified 2D or 3D object. ii) The method results in a simple, yet recursively constructable design layout that is inherently interlocked. iii) Almost all steps within the proposed design procedure can be automated and we present algorithms and a base-version implementation for the same. Wetlab validation showing the results of self-assembly of our first batch of computer generated 2D models is presented.
Starting Page	379
Ending Page	383
File Size	716342
Page Count	5
File Format	PDF
ISBN	9780769538853
DOI	10.1109/BIBM.2009.71
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-11-01
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Algorithm design and analysis Process design Medical robotics Shape Hilbert space filling curve Software algorithms Nanostructures Application software synthetic biology Self-assembly DNA DNA nanosynthesis computational modeling Nanotechnology
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in