NDLI: Discovery of cancer-related new drug target proteins from re-constructed human disease network based on protein-protein interaction netowk

Content Provider	IEEE Xplore Digital Library
Author	Yoon Kyeong Lee Hak Yong Kim
Copyright Year	2009
Description	Author affiliation: Department of Bio and Information Technology, Chungbuk National University, Cheongju, Republic of Korea (Yoon Kyeong Lee) \|\| Department of Biochemistry, CBITRC, MEST, KOTEF, Chungbuk National University, Cheongju, Republic of Korea (Hak Yong Kim)
Abstract	Experimental methods such as high-throughput screening have widely used for discovery of the new drug targets. We employed an idea that disease-related proteins tend to be work as an important factor for architecture of the disease network in this study. To determine new drug target proteins, we proposed a new methodology that analyzes the human disease network by using informational technology. We re-constructed cancer-related human disease network based on the protein-protein interaction network. We derived 105 cancer related new drug-target proteins from the disease network. To evaluate our method, first of all, we extracted the cancer-related target genes that independently obtained from the human gene network introduced by Barabasi et al [1]. The cancer-related target genes and proteins compared with cancer-related target gene dataset obtained from DrugBank. Our results from disease-related network have 81% identity with the cancer-related target genes (164) from the DrugBank. In contrast, the target genes from the human gene network have only 71% identity. These results suggest that our new methodology will contribute for discovering drug target proteins.
Starting Page	351
Ending Page	351
File Size	53450
Page Count	1
File Format	PDF
ISBN	9781424451210
DOI	10.1109/BIBMW.2009.5332070
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-11-01
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Drugs Disruption tolerant networking Protein-protein interaction network Pharmaceutical technology Humans Biochemistry Information technology Diseases Information analysis Proteins Disease network Drug-target protein Cancer
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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