NDLI: Towards understanding the nature of high frequency backscatter from cells and tissues: an investigation of backscatter power spectra from different concentrations of cells of different sizes

Content Provider	IEEE Xplore Digital Library
Author	Kolios, M.C. Czarnota, G.J. Worthington, A. Giles, A. Tunis, A.S. Sherar, M.D.
Copyright Year	2005
Description	Author affiliation: Dept. of Math., Phys. & Comput. Sci., Ryerson Univ., Toronto, Ont., Canada (Kolios, M.C.; Czarnota, G.J.)
Abstract	During cell death, a series of structural changes occur within the cell. We have shown that cell ensembles and tissues undergoing structural changes associated with various cell death pathways can be detected using high-frequency ultrasound. In our effort to understand better the nature of backscatter from collections of cells (which emulate tissues), we have collected raw RF backscatter data from cells of two different sizes (human acute myeloid leukemia, AML, cells and transformed prostate cells) in solutions for a series of concentrations or in pellet form. It was found that the backscatter power (as measured by the mid-band fit) increased by /spl sim/3 dB for both cell types in dilute solutions for which the volumetric concentration was doubled for a specific range of cell concentrations (which was dependent on cell size). In pellet form, the backscatter power from the prostate cell pellets was /spl sim/12-14 dB greater than the AML cell pellets. A comparison of the spectral slopes also strongly suggests a change in the scattering source contributions when the cells are in pellets: the spectral slope was negative for all concentrations for prostate cells imaged at 40 MHz, but positive when measured in pellets. This is consistent with an increased contribution to the backscatter of smaller sized scatterers (such as the cell nucleus) that manifests itself only when the cells are in pellets but not in solution. These data are compared to theoretical predictions and their significance discussed.
Starting Page	606
Ending Page	609
File Size	1566270
Page Count	4
File Format	PDF
ISBN	0780384121
ISSN	10510117
DOI	10.1109/ULTSYM.2004.1417798
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2004-08-23
Publisher Place	Canada
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Backscatter Frequency Scattering Ultrasonic imaging Power measurement Ultrasonic transducers Mathematics Physics Computer science Biomedical imaging
Content Type	Text
Resource Type	Article

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