NDLI: On-Line Error Detection in Digital Microfluidic Biochips

Content Provider	IEEE Xplore Digital Library
Author	Mitra, D. Ghoshal, S. Rahaman, H. Chakrabarty, K. Bhattacharya, B.B.
Copyright Year	2012
Abstract	Digital micro fluidic technology is being increasingly used for implementing a lab-on-a-chip with many life-critical applications. Testing of these biochips is thus indispensable not only after manufacture, but also during in-field operation. To keep the product cost (including both design and test) low for disposable biochips, efficient on-line test techniques are desirable. All previous on-line test mechanisms interleave testing and the target bioassay protocol, but they involve overhead such as use of separate test droplet(s) and increased completion time. In this paper, we propose a simple on-line error-detection methodology that can be performed concurrently with the normal operation of the system with no or little extra effort. The proposed procedure does not require any test droplet. In the case of incorrect operation, the error is detected on or before the completion of the bioassay. The main objective of the proposed strategy is to ensure the correctness of the executed assay on-chip and not to guarantee the absence of a defect in the chip. The given assay protocol is assumed to be executed correctly if the on-line procedure finishes with success. The assay is aborted as soon as an error is detected, thereby saving costly sample/reagents. Moreover, the scheme can be easily adopted to enhance diagnosis.
Starting Page	332
Ending Page	337
File Size	223908
Page Count	6
File Format	PDF
ISBN	9781467345552
ISSN	10817735
e-ISBN	9780769548760
DOI	10.1109/ATS.2012.56
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-11-19
Publisher Place	Japan
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Reservoirs Testing Circuit faults Electrodes Arrays Transportation Detectors on-line testing Biochips diagnosis digital microfluidics error detection
Content Type	Text
Resource Type	Article
Subject	Electrical and Electronic Engineering

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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