NDLI: Systematic study of enhanced cytotoxicity effects of gold-based nanoparticles in targeted cancer radiotherapy

Content Provider	IEEE Xplore Digital Library
Author	Kun Song Peng Xu Yongde Meng Jie Chen Xiaoyan Yang Roa, W. Beihua Kong James Xing
Copyright Year	2009
Description	Author affiliation: Department of Biomedical Engineering, University of Alberta, Edmonton, Canada (Peng Xu; Yongde Meng; Jie Chen; Xiaoyan Yang) \|\| Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Ji'nan, China (Kun Song; Beihua Kong) \|\| Cross-cancer Institute, Edmonton, Alberta, Canada (Roa, W.; James Xing)
Abstract	Worldwide, cancers are the leading causes of human mortality. To successfully treat advanced-stage cancers, it is important to increase cytotoxicity of targeted tumor cells while reducing side effects on normal cells during radiotherapy. Nanotechnology provides a promising solution to achieve this targeted $treatment^{[1–3]}.$ An ideal strategy is to develop effective nanoscale radio-sensitizers targeting specifically at tumor cells. In this paper, we focus on gold-based nanoparticles as radio-sensitizers. Naked gold nanoparticles (GNPs) can accumulate at tumor tissues based on passively targeting mechanism and thus it can be used as a radio-sensitizer to kill cancers. However, GNPs conjugated with tumor-specific ligands are more promising for tumor diagnosis and treatment at the molecular scale. We have designed glucose-capped GNPs (or Glu-GNPs) to achieve specific targeting. Our preliminary results show a remarkable increase in cell-uptake of Glu-GNPs and also a significant increase of radiation cytotoxicity after applying irradiations.
Starting Page	33
Ending Page	35
File Size	446385
Page Count	3
File Format	PDF
ISBN	9781424442928
DOI	10.1109/LISSA.2009.4906702
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-04-09
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Nanoparticles Cancer Neoplasms Biomedical engineering Nanotechnology Humans Tumors Paramagnetic resonance In vivo Gynaecology
Content Type	Text
Resource Type	Article

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