NDLI: Investigation of smoking related features in spatio-spectral domain on resting-state fMRI data using nonnegative matrix factorization

Content Provider	IEEE Xplore Digital Library
Author	Xiaoyu Ding Jong-Hwan Lee Seong-Whan Lee
Copyright Year	2012
Description	Author affiliation: Department of Brain and Cognitive Engineering, Korea University, Seoul, Republic of Korea (Jong-Hwan Lee; Seong-Whan Lee) \|\| Department of Computer Science and Engineering, Korea University, Seoul, Republic of Korea (Xiaoyu Ding)
Abstract	Smoking is a typical exemplar in drug addiction researches for the wide range of tobacco users. The presented study uses functional magnetic resonance imaging (fMRI) to explore the resting-state (RS) neural mechanisms associated with smoking deprivation. We propose a novel analysis approach which applies nonnegative matrix factorization (NMF) algorithm on spatially concatenated two group datasets to investigate smoking related RS features in spatio-spectral domain. The NMF algorithm decomposed the magnitude spectra of fMRI time series into distinct frequency-specific basis functions and corresponding nonnegative spatial maps. After a two sample T-test on the z-scored spatial maps between groups, representative feature regions such as insula, anterior cingulate cortex and precuneus were found to be associated with smoking. These regions were consistent with that revealed by previous literatures studying in spatio-temporal domain. It indicates that our proposed analysis method provides another option for exploring neural mechanism differences between two groups, which might be used in a range of applications.
Starting Page	571
Ending Page	574
File Size	557876
Page Count	4
File Format	PDF
ISBN	9781467317139
e-ISBN	9781467317146
e-ISBN	9781467317122
DOI	10.1109/ICSMC.2012.6377786
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-10-14
Publisher Place	Korea (South)
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Matrix decomposition Algorithm design and analysis Magnetic resonance imaging Transmission line matrix methods Drugs Time series analysis Band pass filters nonnegative matrix factorization smoking addiction resting-state
Content Type	Text
Resource Type	Article

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