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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Ting-Hsuan Chen Leiting Pan Xiaolu Zhu Chih-Ming Ho |
| Copyright Year | 2013 |
| Description | Author affiliation: Mechancial & Aerosp. Eng. Dept., Univ. of California, Los Angeles, Los Angeles, CA, USA (Xiaolu Zhu; Chih-Ming Ho) || Dept. of Mech. & Biomed. Eng., City Univ. of Hong Kong, Hong Kong, China (Ting-Hsuan Chen) || Key Lab. of Weak-Light Nonlinear Photonics, Nankai Univ., Tianjin, China (Leiting Pan) |
| Abstract | Creating patterns of constituent ingredients are essential for tissue regeneration. Using vascular mesenchymal cells (VMCs) which spontaneously aggregate into multicellular structure, we demonstrate a MEMS-based method to direct the assembly of VMCs into desired tissue patterns. Incorporating the inherent chirality of VMCs revealed by micro-engineered substrates, differences in initial cell plating can be amplified into the formation of exquisite radial structures resembling the crosssectional structure of liver lobules. Furthermore, when cocultured with VMCs, vascular endothelial cells (ECs) tracked with the VMCs and formed a coherent radial pattern, indicating the applicability to heterotypical cell organization. We envision method has broad implications for building instructive microenvironment for tissue engineering. |
| Starting Page | 328 |
| Ending Page | 331 |
| File Size | 5730685 |
| Page Count | 4 |
| File Format | |
| e-ISBN | 9781467363525 |
| e-ISBN | 9781467363518 |
| DOI | 10.1109/NEMS.2013.6559743 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2013-04-07 |
| Publisher Place | China |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Substrates Educational institutions Cells (biology) Aggregates Tissue engineering Organizations Muscles self-assembly micropatterning tissue morphogenesis |
| Content Type | Text |
| Resource Type | Article |
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