NDLI: Presenting a Novel Neural Network Architecture for Membrane Protein Prediction

Content Provider	IEEE Xplore Digital Library
Author	Bose, S.K. Kazemian, H. Browne, A. White, K.
Copyright Year	2006
Description	Author affiliation: Dept. of Comput., Commun. Technol. & Math., London Metropolitan Univ. (Bose, S.K.; Kazemian, H.)
Abstract	In the early seventies, it was clear that primary amino acid sequence and its local solution environment hold most of the information necessary for protein folding. Since then, scientists have been trying to solve the bioinformatics problem by constructing the tertiary three-dimensional structure of protein from the primary amino acid sequences by using computational biology. Success of several genome sequencing projects put considerable momentum in an effort to analyze these bio-chemically uncharacterized sequence. A handful of methods are developed to solve the problem of globular proteins prediction because of the easy availability of the data but the prediction of membrane protein structures is a key area that remains mainly unsolved. The problem of prediction is made topologically more complex by the presence of several transmembrane domains in many proteins, and current tools are far away from achieving significant reliability in prediction. But from a pharmaeconomical perspective, though it is the fact that membrane proteins constitute ~ 75% of possible targets for novel drugs but MPs are one of the most understudied groups of proteins in biomedical research. In this paper we present novel neural networks (NNs) architecture and algorithms for predicting membrane spanning regions from primary amino acids sequences by using their preference parameters
Starting Page	135
Ending Page	138
File Size	3725876
Page Count	4
File Format	PDF
ISBN	0780397088
DOI	10.1109/INES.2006.1689356
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-06-26
Publisher Place	UK
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Neural networks Biomembranes Sequences Amino acids Bioinformatics Protein engineering Computational biology Genomics Availability Drugs ROC and AUC Membrane Proteins Neural Networks Knowledge Discovery Secondary Structure Prediction Amino acid encoding
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in