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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Xue Du Shao-Wu Zhang |
| Copyright Year | 2010 |
| Description | Author affiliation: School of Automation, Northwestern Polytechnical University, Xi'an 710072, China (Xue Du; Shao-Wu Zhang) |
| Abstract | Fast and effective prediction of signal peptides and their cleavage sites is of great importance in computational biology. There are two kinds of approaches developed to predict signal peptides, one of which based on model training approach such as SignalP and SPEPlip, and another based on sliding window method such as PrediSi, Signal-CF and Signal-3L. In this paper, the scaled window method proposed by Chou was employed to extract cleavable secretory segments, and template matching fusion method (named as Signal-TMF) was introduced to predict signal peptide cleavage sites. Comparing with Chou's Signal-CF method, the best overall accuracy of Signal-TMF is 6–15% higher than of Chou's in jackknife test. The Signal-TMF can also be used to effectively predict the long signal peptide cleavage site. The results show that Signal-TMF will be very useful to the areas related to signal peptides. |
| Starting Page | 1801 |
| Ending Page | 1804 |
| File Size | 126078 |
| Page Count | 4 |
| File Format | |
| ISBN | 9781424458974 |
| e-ISBN | 9781424459001 |
| DOI | 10.1109/ICOSP.2010.5656676 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2010-10-24 |
| Publisher Place | China |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Peptides Proteins Prediction algorithms Benchmark testing Protein engineering Amino acids Accuracy scaled window signal peptide cleavage site template matching fusion |
| Content Type | Text |
| Resource Type | Article |
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