NDLI: A design method of DNA chips for SNP analysis using self-organizing maps

Content Provider	IEEE Xplore Digital Library
Author	Douzono, H. Hara, S. Noguchi, Y.
Copyright Year	2001
Description	Author affiliation: Fac. of Sci. & Eng., Saga Univ., Japan (Douzono, H.)
Abstract	We introduce a design method of DNA chips using self-organizing maps (SOM). DNA chips are powerful tools for sequencing and SNP (single nucleotide polymorphism) analyses of DNA sequences. A DNA chip is an array of DNA probes which are hybridized with the compliment sub-sequences in the target sequence. However, conventional DNA chips are showing tendency to be comprised of longer probes and get larger in size to achieve a higher resolution. To shrink the size of DNA chips, the design is considered to be important. To solve this problem, we applied SOM to obtain common features of DNA sequences with small number of probes which efficiently cover the target sequence with sufficient resolution for finding the correct position of SNPs. We evaluated the DNA chips designed by SOM with computer simulations of SNP analyses, changing the length of probes and size of the maps.
Sponsorship	Int. Neural Network Soc.
Starting Page	2467
Ending Page	2471
File Size	436073
Page Count	5
File Format	PDF
ISBN	0780370449
ISSN	10987576
DOI	10.1109/IJCNN.2001.938754
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2001-07-15
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Design methodology Self organizing feature maps Sequences Probes Genomics Bioinformatics Computer vision Power engineering and energy DNA computing Humans
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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