NDLI: Experimental condition and registration method for the tumor detection of lung metastasis small animal PET and CT whole body images

Content Provider	IEEE Xplore Digital Library
Author	Sang-Keun Woo KyungMin Kim Taesup Lee JuneYeop Kim JaeHo Jung KwangSun Woo WeeSup Jung JooHyun Kang GiJeong Cheon ChangWoon Choi SangMoo Lim
Copyright Year	2007
Description	Author affiliation: Korea Inst. of Radiol. & Med. Sci., Seoul (Sang-Keun Woo; KyungMin Kim; Taesup Lee; JuneYeop Kim; JaeHo Jung; KwangSun Woo; WeeSup Jung; JooHyun Kang; GiJeong Cheon; ChangWoon Choi; SangMoo Lim)
Abstract	Small animal PET scanning with $^{18}F-FDG$ is increasingly used in murine tumor model. Experimental condition of animal handling impacts on the biodistribution of $^{18}F-FDG$ in mouse study. The aim of this study was to optimize experimental conditions of animal handling and registration method for imaging lung metastasis tumor by using $^{18}F-FDG$ small animal PET and CT. The experimental conditions for $^{18}F-FDG$ biodistribution and animal PET imaging were 20 plusmn 2 h fasting and warming kept at 30degC. Biodistribution, standard uptake value (SUV) image and glucose SUV $(SUV_{G})$ of $^{18}F-FDG$ were evaluated and blood glucose level was also measured. Female C57BL/6 mice were injected intravenously with 2 times $10^{5}$ of B16-F10 melanoma cells which developed metastasis tumors in lung. In lung metastasis tumor model, $^{18}F-FDG$ images was obtained in optimized anesthesia condition and registered with anatomical clinical CT image. The small animal PET and CT images were registered using the hardware fiducial markers and small animal contour point in both data sets to perform a point- based rigid registration. Isoflurane 0.5 condition was chosen for lung metastasis tumor imaging. Lung metastasis tumor was clearly visualized by $^{18}F-FDG$ PET image with Iso 0.5 anesthesia. Tumor imaging in lung region with $^{18}F-FDG$ small animal PET should be considered feeding, temperature, and especially choice and level of anesthetic for minimizing background radioactivity. Fused imaging with small animal PET and CT image could be useful for the detection of metastatic tumor. This method improves the quantitative accuracy and interpretation of the tracer.
Starting Page	3372
Ending Page	3375
File Size	222831
Page Count	4
File Format	PDF
ISBN	9781424409228
ISSN	10957863
DOI	10.1109/NSSMIC.2007.4436855
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2007-10-26
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Tumors Metastasis Animals Whole-body PET Computed tomography Lung neoplasms Positron emission tomography Mice Sugar Anesthesia
Content Type	Text
Resource Type	Article

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