NDLI: A 5-dimensional mathematical model for regional and global changes in cardiac uptake and motion

Content Provider	IEEE Xplore Digital Library
Author	Pretorius, P.H. King, M.A. Gifford, H.C.
Copyright Year	2004
Description	Author affiliation: Massachusetts Univ. Med. Sch., Worcester, MA, USA (Pretorius, P.H.; King, M.A.; Gifford, H.C.)
Abstract	The objective of this work was to simultaneously introduce known regional changes in contraction pattern and perfusion to the existing gated mathematical cardiac torso (MCAT) phantom heart model. We derived a simple integral to calculate the fraction of the ellipsoidal volume that make up the LV, taking into account the stationary apex and the moving base. After calculating the LV myocardium volume of the existing beating heart model, we use the property of conservation of mass to manipulate the LV ejection fraction to values ranging between 13.5% and 68.9%. Multiple dynamic heart models that differ in degree of LV wall thickening, base-to-apex motion, and ejection fraction, are now available to use with the existing MCAT methodology. To introduce more complex regional LV contraction and perfusion patterns, composites of dynamic heart models are used to create a central region with no or little motion and/or perfusion and a changeover to the normal motion and/or perfusion. Gated cardiac acquisitions for different clinical situations were simulated analytically: 1) a reduced regional motion and perfusion (50% and 75% of normal); 2) same perfusion as in (1) without motion intervention; and 3) washout from the normal myocardium of the LV to 20% of normal, with a reduction to only 40% of normal in the diseased region. Both motion and perfusion can change dynamically during a single rotation or multiple rotations of a simulated SPECT acquisition system.
Starting Page	3150
Ending Page	3154
File Size	765663
Page Count	5
File Format	PDF
ISBN	0780382579
ISSN	10823654
DOI	10.1109/NSSMIC.2003.1352565
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2003-10-19
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Mathematical model Heart Imaging phantoms Myocardium Torso Motion analysis Testing Analytical models Robustness Animals
Content Type	Text
Resource Type	Article

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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