NDLI: Photon migration theory applied to 3D optical imaging of tissue

Content Provider	IEEE Xplore Digital Library
Author	Gandjbakhche, A.H. Gannot, I. Bonner, R.F.
Copyright Year	1996
Description	Author affiliation: DCRT Phys. Sci. Lab., Nat. Inst. of Health, Bethesda, MD, USA (Gandjbakhche, A.H.)
Abstract	Noninvasive optical spectroscopic imaging of tissue has considerable potential for clinical screening and monitoring metabolic status, if accurate tomographic reconstruction techniques are developed. The rationale for specific diagnosis is based on different spectroscopic signatures of intrinsic tissue or specific exogenous labels which can distinguish between normal and abnormal tissue types. However, several critical technological elements are required for clinically useful imaging. These include obtaining a balance between attenuation of the detected light and resolution, and achieving specificity which is crucial for a purely noninvasive, definitive diagnosis. The authors use random walk theory to address these interrelated elements by calculating a time-dependent contrast function to describe photon paths in time-resolved transillumination detection of abnormally absorbing and/or scattering regions in tissue. The contrast function depends on the optical properties of the normal tissue as well as the optical properties, size and location of the abnormal target. Results of the theory are applied to estimate the absorption and the scattering coefficients of a cylinder embedded in a tissue-like phantom. Although the authors were able to detect the presence of the abnormal target and quantify its optical properties, the specificity of such quantitation is yet to be demonstrated. In fact, differences in scattering properties between normal and abnormal tissue can be rather nonspecific. Moreover, at near infra-red wavelengths in which the optical attenuation in tissue is rather small differences in absorptivity between normal and diseased tissue can be quite small. This implies poor contrast and therefore poor resolvability of a target from other tissue components.
File Size	97103
File Format	PDF
ISBN	0780331605
DOI	10.1109/LEOS.1996.565300
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	1996-11-18
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Optical imaging Optical scattering Optical attenuators Light scattering Particle scattering Spectroscopy Monitoring Tomography Image reconstruction Absorption
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in