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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Previti, C. Harari, O. del Val, C. |
| Copyright Year | 2007 |
| Description | Author affiliation: German Cancer Res. Inst. (DKFZ), Heidelberg (Previti, C.) |
| Abstract | A DNA sequence can be described as a string composed of four symbols: A, T, C and G. Each symbol represents a chemically distinct nucleotide molecule. Combinations of two nucleotides are called dinucleotides and CpG islands represent regions of a DNA sequence, certain substrings, which are enriched in CpG dinucleotides (C followed by G). CpG islands represent a prominent and enigmatic feature of vertebrate genomes. They are associated with the promoters of more than 60% of all human genes and represent a critical target for transcriptional control. Methylation of these CpG islands leads to structural changes in the DNA that stops the expression of any associated gene (gene-silencing). The factors that provoke or impede methylation are currently all but unknown. In general, the maintenance of a particular pattern of methylated CpG dinucleotides represents a critical regulatory system during a host of normal developmental processes, but the erroneous methylation of CpG islands and the resulting gene-silencing can lead to the development of cancer. In this work, we present a novel unsupervised machine learning method that is capable of distinguishing biologically significant classes of CpG islands, including the separation of methylated and unmethylated CpG islands. This method represents an important novel approach that will aid in the computational prediction of methylation, which is commonly used in the pre-selection of worthwhile sequences for methylation experiments. |
| Starting Page | 1 |
| Ending Page | 6 |
| File Size | 3854225 |
| Page Count | 6 |
| File Format | |
| ISBN | 1424412099 |
| ISSN | 10987584 |
| DOI | 10.1109/FUZZY.2007.4295540 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2007-07-23 |
| Publisher Place | UK |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | DNA Sequences Chemicals Genomics Bioinformatics Humans Impedance Cancer Learning systems Biology computing |
| Content Type | Text |
| Resource Type | Article |
| Subject | Applied Mathematics Artificial Intelligence Theoretical Computer Science Software |
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