NDLI: The study of a cell-based TSM piezoelectric sensor

Content Provider	IEEE Xplore Digital Library
Author	Barbee, K. Sun Kwoun Lec, R.M. Sorial, J.
Copyright Year	2002
Description	Author affiliation: Dept. of Electr. & Comput. Eng., Drexel Univ., Philadelphia, PA, USA (Barbee, K.; Sun Kwoun; Lec, R.M.; Sorial, J.)
Abstract	Piezoelectric biosensors incorporating living cells are capable of delivering functional information in contrast to protein-based sensors, which provide analytical data. Functional information, i.e. information about the physiological effect of an analyte or measurand on a living system, is often desired in many important applications in pharmacology, toxicology, cell biology and environmental measurements, including the applications in the area of bioterrorism and biowarfare. Preliminary results describing the properties of a thickness shear mode (TSM) acoustic sensor operating under different ambient conditions with immobilized endothelial cells are presented. A TSM acoustic sensor, which utilizes shear motion generated by a vibrating AT-cut quartz resonator, has the ability to monitor interfacial phenomena at the sensor/liquid interface. The cells were placed in Dulbecco's modified Eagles media (DMEM) solution, which provided appropriate conditions for maintaining cells at the required level of bioactivity. Initially, the sensor was calibrated with well characterized physical system consisting of a suspension of polystyrene spheres in DMEM. Next, the immobilization process of the cells onto various solid surfaces was characterized. A sedimentation rate and different arrangements of the cells at the gold and collagen surfaces were determined.. Specifically, the adhesion period followed by the cell proliferation time were measured, and unique signatures of the sensor response corresponding to each of these processes were identified. Finally, the cells were fixed with formaldehyde, which manifested itself with the increase of the cell elasticity and decrease of the viscoelastic losses. In conclusion, TSM piezoelectric sensors offer a very attractive technology platform for development of cell-based biosensors. Because a cell-based sensing process is physiologically relevant to natural cellular machinery, these sensor types will experience growing significance in the near future.
Sponsorship	IEEE Ultrasonics, Ferroelectrics, & Frequency Control Soc
Starting Page	260
Ending Page	267
File Size	732221
Page Count	8
File Format	PDF
ISBN	0780370821
DOI	10.1109/FREQ.2002.1075886
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2002-05-31
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Biosensors Acoustic sensors Sensor phenomena and characterization Information analysis Biomedical monitoring Acoustic measurements Area measurement Elasticity Proteins Data analysis
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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