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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Chia-Hung Chang Bor-Sen Chen Yung-Jen Chuang |
| Copyright Year | 2008 |
| Description | Author affiliation: Dept. of Electr. Eng., Nat. Tsing Hua Univ., Hsinchu (Chia-Hung Chang) |
| Abstract | A robust model matching control of immune response is proposed for therapeutic enhancement to match a prescribed immune response under uncertain initial states and environmental disturbances, including continuous intrusion of exogenous pathogens. The worst-case effect of all possible environmental disturbances and uncertain initial states on the matching for a desired immune response is minimized for the enhanced immune system, i.e. a robust control is designed to track a prescribed immune model response from the minimax matching perspective. This minimax matching problem could be transformed to an equivalent dynamic game problem. The exogenous pathogen and environmental disturbances are considered as a player to maximize (worsen) the matching error when the therapeutic control agents are considered as another player to minimize the matching error. Since the innate immune system is highly nonlinear, it is not easy to solve the robust model matching control problem by the nonlinear dynamic game method directly. A fuzzy model is proposed to interpolate several linearized immune systems at different operation points to approximate the innate immune system via smooth fuzzy membership functions. With the help of fuzzy approximation method, the minimax matching control problem of immune systems could be easily solved by the proposed fuzzy dynamic game method via the linear matrix inequality (LMI) technique with the help of robust control toolbox in Matlab. Finally, an in silico example is given to illustrate the design procedure and to confirm the efficiency and efficacy of the proposed method. |
| Starting Page | 2087 |
| Ending Page | 2092 |
| File Size | 688798 |
| Page Count | 6 |
| File Format | |
| ISBN | 9781424418220 |
| DOI | 10.1109/CEC.2008.4631075 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2008-06-01 |
| Publisher Place | China |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Immune system Games Mathematical model Robustness Nonlinear dynamical systems Approximation methods Computational modeling LMI Immune systems pathogen-host interaction network robust control dynamic game theory desired immune response fuzzy dynamic game |
| Content Type | Text |
| Resource Type | Article |
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