NDLI: In silico survey of distribution and frequency of imperfect microsatellite repeats in viral genomes

Content Provider	IEEE Xplore Digital Library
Author	Mudunuri, S.B. Mishra, P. Nagarajaram, H.A.
Copyright Year	2012
Description	Author affiliation: Dept. of Computer Science & Engineering, Vishnu Institute of Technology, Bhimavaram, Andhra Pradesh, India 534 202 (Mudunuri, S.B.) \|\| Lab. of Computational Biology, Centre for DNA Fingerprinting and Diagnostics (CDFD), Hyderabad, Andhra Pradesh, India 500 001 (Mishra, P.)
Abstract	Microsatellites are short, dynamic tandem repeats in DNA sequences that are unique in nature and are widely used in several fields including DNA Fingerprinting, Paternity Studies, Forensics, Population Studies and Evolutionary studies. This paper presents the first comprehensive computational study of microsatellite repeats in viruses. Microsatellites from more than 3,500 viral sequences have been analyzed to underpin the genomic differences in them, their variation in terms of size and genes, distribution of microsatellite repeats based on their motif-size, location and also the motif preferences of such microsatellite repeats in all these sequences. The study revealed that the viral genomes differ a lot in terms of their genome composition and also in terms of the microsatellite distribution. We found that the majority of microsatellites are in the coding regions suggesting selection towards pathogen adaptation and faster evolution. It is also observed that viruses are selective in nature to form microsatellites with certain motifs only.
Starting Page	31
Ending Page	36
File Size	145020
Page Count	6
File Format	PDF
ISBN	9781467321488
e-ISBN	9781467321495
DOI	10.1109/ICDSE.2012.6282303
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-07-18
Publisher Place	India
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Microsatellites RNA DNA Viruses Genomics Standardization Microsatellite Distribution Viruses Encoding Genomes Repeats Motifs DNA RNA Viruses Viruses (medical) Retro Viruses
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in